Serum monoterpene levels, glucose homeostasis, lipid profiles, and metabolic syndrome in adults: NHANES, 2013–2014  

作　　者：Wei-Jie Wang Yu-Ling Lin Chikang Wang Chien-Yu Lin 

机构地区：[1]Division of Nephrology,Department of Internal Medicine,Taoyuan General Hospital,Ministry of Health and Welfare,Taoyuan,330,Taiwan,China [2]Department of Biomedical Engineering,Chung Yuan Christian University,Taoyuan,300,Taiwan,China [3]Department of Nephrology,Hsinchu Cathay General Hospital,Hsinchu,300,Taiwan,China [4]Department of Healthcare Management,Yuanpei University of Medical Technology,Hsinchu,300,Taiwan,China [5]Department of Environmental Engineering and Health,Yuanpei University of Medical Technology,Hsinchu,300,Taiwan,China [6]Department of Internal Medicine,En Chu Kong Hospital,New Taipei City,237,Taiwan,China [7]School of Medicine,Fu Jen Catholic University,New Taipei City,242,Taiwan,China

出　　处：《Emerging Contaminants》2024年第2期33-39,共7页新兴污染物（英文）

基　　金：This study would not have been possible without the collective efforts and support of numerous individuals and organizations.This study was funded by grants from the Ministry of Science and Technology of Taiwan NSC 110-2314-B-385-001-MY3.

摘　　要：Monoterpenes are organic compounds which have been studied for their medicinal benefits.However,the association between monoterpene exposure and metabolic parameters in humans is unknown.We investigated the connection between three specific monoterpenes(α-pinene,β-pinene,and limonene),glucose homeostasis biomarkers,lipid profiles,and metabolic syndrome(MS)in 1627 adults from the National Health and Nutrition Examination Survey(NHANES)2013–2014.We found serum levels ofα-pinene andβ-pinene were positively associated with fasting glucose,total cholesterol,triglyceride,and apolipoprotein B.In addition,increased levels of limonene andΣmonoterpene(sum of three monoterpene chemicals)were linked to higher insulin,β-cell function,total cholesterol,low density lipoprotein cholesterol(LDL-C),triglycerides,and apolipoprotein B.Participants with all three monoterpenes above the 50th percentile had notably higher values for total cholesterol and triglycerides compared to those with all three monoterpenes below the 50th percentile(P for trend<0.001).Regarding MS,higher serum concentrations ofα-pinene were linked to an increased risk of high-density lipoprotein cholesterol(HDL-C)insufficiency and hypertriglyceridemia.Elevated concentrations ofβ-pinene were associated with a higher prevalence of hypertriglyceridemia.Moreover,increased levels of limonene andΣmonoterpene were connected to a higher risk of MS,larger waist circumference,low HDL-C,hypertriglyceridemia,and higher blood pressure according to MS criteria.In conclusion,serum monoterpenes levels were linked to glucose regulation,lipid profiles,and indicators of MS.Further studies are necessary to clarify the potential causal relationships.

关 键 词：Glucose homeostasis Lipid profiles MONOTERPENES National health and nutrition examination survey(NHANES) 

分 类 号：O62[理学—有机化学]