Chemical degradation of platinum oncolytics in urine and speciation of the inorganic contaminants cisplatin and carboplatin relevant in waste water  

作　　者：Karel Folens Janis Baeten Karen Couvreur Gijs Du Laing 

机构地区：[1]Laboratory of Analytical Chemistry and Applied Ecochemistry(ECOCHEM),Department of Green Chemistry and Technology,Ghent University,Frieda Saeystraat 1,9052,Zwijnaarde,Belgium [2]Center for Microbial Ecology and Technology(CMET),Department of Biotechnology,Ghent University,Coupure Links 653,9000,Gent,Belgium [3]Medical Oncology,AZ Glorieux,Glorieuxlaan 55,9600,Ronse,Belgium

出　　处：《Emerging Contaminants》2024年第1期47-53,共7页新兴污染物（英文）

摘　　要：Understanding the prevalent form of platinum(Pt)based antineoplastic agents,used in chemotherapy,is of importance to develop a remediation strategy that restricts aquatic exposure.The speciation of Pt-based compounds was measured in actual patients’urine using hydrophobic interaction liquid chromatography(HILIC)equipped with an ICP-MS detector.Carboplatin showed poor metabolization and intact excretion 11 h after administration,whereas cisplatin underwent a rapid aquation in the first 7 h.To compare,the in vitro degradation rate of cisplatin,carboplatin and oxaliplatin was determined in synthetic human urine,mimicking true environmental conditions.The fraction of intact molecules was measured at regular intervals following incubation at 37°C,resulting in degradation rate constants.The chemical stability was highest for carboplatin(k=0.0143±0.0012 min−1),versus faster degradation of oxaliplatin and cisplatin by exponential decay with k1 of 0.0026±0.0001 min−1 and k_(2)=5.59±0.46×10^(−6) min−1,respectively.These kinetic parameters can serve as input to further expand modelling databases and improve the predictive power of speciation software to estimate eco-toxicity risks.Considering the strong residual cytotoxicity of the platinum antineoplastic molecules following renal clearance and human excretion,the contaminants are of high environmental concern and offer potential for metal recovery using advanced treatment steps.In such water treatment processes,especially carboplatin,above all cancerostatic platinum compounds,should be addressed since it is more persistent in the aquatic environment.

关 键 词：Pharmaceuticals Inorganic contaminants Speciation analysis ECOTOXICITY 

分 类 号：X703[环境科学与工程—环境工程]