补肾健脾方联合八段锦对多囊卵巢综合征的治疗效果  

Therapeutic Effect of Bushen Jianpi Formula Combined with Baduanjin Exercise on Polycystic Ovary Syndrome

作　　者：刘芳 徐铮铮 Liu Fang;Xu Zhengzheng(The First Clinical College,Hubei University of Chinese Medicine,Wuhan 430065,China;Department of Gynecology,Xinhua Hospital Affiliated to Hubei University of Chinese Medicine,Wuhan 430010,China;Department of Gynecology,Hubei Provincial Hospital of Integrated Chinese and Western Medicine,Wuhan 430010,China)

机构地区：[1]湖北中医药大学第一临床学院,武汉430065 [2]湖北中医药大学附属新华医院妇科,武汉430010 [3]湖北省中西医结合医院妇科,武汉430010

出　　处：《成都医学院学报》2024年第5期841-845,850,共6页Journal of Chengdu Medical College

基　　金：湖北省中医药管理局中医药科研项目(No:ZY2023M012)。

摘　　要：目的观察补肾健脾方联合八段锦治疗肾虚痰湿型多囊卵巢综合征(PCOS)患者的疗效。方法选取2022年1月至2023年12月于湖北省中西医结合医院就诊的104例PCOS患者为研究对象,随机将其分为A组(n=36)、B组(n=35)和C组(n=33)。A组以炔雌醇环丙孕酮片治疗,B组在A组基础上附加补肾健脾方治疗,C组在B组基础上增加八段锦治疗。比较治疗前(T0)、治疗停止后次日(T1)和治疗停止后3个月的月经来潮第2~4天(T2)3组中医证候积分、毛发评分、痤疮等级评分、体重指数(BMI);比较T0、T23组血清性激素指标、卵巢储备功能、空腹血糖(FPG)和血清瘦素(LP)水平;比较治疗期间3组不良反应发生情况;比较3组T2月经恢复情况及治疗总有效率。结果与T0比较,T1、T23组中医证候积分、毛发评分、痤疮等级、BMI水平明显降低,且C组明显低于A、B组(P<0.05)。与T0比较,3组T2卵泡数量和卵巢体积以及血清FSH、LH、T、AMH、LP、FPG水平均明显降低,且C组明显低于A、B组(P<0.05);与T0比较,3组T2血清E2水平明显升高,且C组明显高于A、B组(P<0.05)。治疗期间C组不良反应发生率明显低于A、B组(P<0.05)。C组T2月经恢复情况及治疗总有效率明显高于A、B组(P<0.05)。结论补肾健脾方联合八段锦可有效改善肾虚痰湿型PCOS患者病情,改善患者卵巢储备功能和血清性激素分泌情况,降低血清LP水平,且安全性良好。Objective To observe the therapeutic effect of Bushen Jianpi formula combined with Baduanjin exercise in treating patients with polycystic ovary syndrome(PCOS)of kidney deficiency and phlegm dampness type.Methods A total of 104 patients with PCOS in Hubei Provincial Hospital of Integrated Chinese and Western Medicine from January 2022 to December 2023 were selected as the research objects.They were randomly divided into group A(n=36),group B(n=35)and group C(n=33).Group A was treated with ethinylestradiol cycloproterenol tablets,group B received additional treatment with Bushen Jianpi decoction on the basis of the treatment in group A,and group C was required to do Baduanjin exercise on the basis of the treatment in group B.The traditional Chinese medicine(TCM)syndrome score,hair score,acne grade score and body mass index(BMI)before treatment(T0),the day after treatment cessation(T1),and the 2nd to 4th day of menstruation 3 months after treatment cessation(T2)were compared among the three groups.The serum sex hormone indicators,ovarian reserve function,fasting plasma glucose(FPG)and serum leptin(LP)level in the three groups at T0 and T2 were compared.The incidence of adverse reactions in the three groups during treatment was compared.The recovery of menstruation at T2 and the total effective rate of treatment were compared among the three groups.Results The TCM syndrome score,hair score,acne grade and BMI at T1 and T2 were reduced in the three groups compared with those at T0,and the above indicators in group C were lower than those in groups A and B(P<0.05).The follicle number,ovarian volume,and serum FSH,LH,T,AMH,LP and FPG levels at T2 were reduced in the three groups compared with those at T0,and the above indicators in group C were lower than those in groups A and B(P<0.05).The serum E2 level at T2 was increased in the three groups compared with that at T0,and that in group C was higher than that in groups A and B(P<0.05).The incidence of adverse reactions during treatment in group C was lower than that in g

关 键 词：多囊卵巢综合征 八段锦 补肾健脾方 卵巢储备功能 血清瘦素 

分 类 号：R711.75[医药卫生—妇产科学]