不同方案阴道乳杆菌活菌胶囊联合甲硝唑治疗细菌性阴道病的临床研究  

Treatment of Bacterial Vaginosis with Different Schemes of Lactobacillius DM8909 Combined with Metronidazole

作　　者：何玲[1] 杜沂岚[2] He Ling;Du Yilan(Department of Gynecology,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610032,China;Department of Integrated Traditonal Chinese and Western Medicine,The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,china)

机构地区：[1]成都中医药大学附属医院妇科,成都610032 [2]成都医学院第一附属医院中西医结合科,成都610500

出　　处：《成都医学院学报》2024年第5期857-860,共4页Journal of Chengdu Medical College

摘　　要：目的研究不同方案阴道乳杆菌活菌胶囊联合甲硝唑治疗有复发危险因素细菌性阴道病(BV)的疗效。方法选取2022年1月至2023年1月在成都中医药大学附属医院收治的有复发危险因素的120例BV患者为研究对象,随机将其分为试验组和对照组,每组60例。试验组口服甲硝唑片0.4 g/次,2次/d,口服7 d,第8天开始每晚用1粒阴道乳杆菌活菌胶囊,连续用药7 d,并在第1、2、3次月经来潮干净3 d后分别使用阴道乳杆菌胶囊塞阴道,每晚1粒,连续用药10 d;对照组口服甲硝唑片0.4 g/次,2次/d,连续用药7 d,同时每晚用1粒阴道乳杆菌活菌胶囊塞阴道,连续用药7 d。比较两组BV的治愈率、复发率、症状改善及阴道微生态恢复情况。结果两组首次临床症状消失的时间比较,差异无统计学意义(P>0.05)。治疗后1个月试验组治愈率及阴道微生态的恢复略高于对照组,但差异无统计学意义(P>0.05)。治疗后3、6个月及1年,试验组BV复发率及阴道微生态的恢复情况明显优于对照组(P<0.05)。与对照组比较,治疗后1年试验组人乳头瘤病毒(HPV)或性传播疾病(STD)转阴率较高(P<0.05)。结论治疗BV时,甲硝唑与阴道乳杆菌活菌胶囊的序贯方案略优于联合方案,但针对有复发危险因素的BV,延长阴道乳杆菌活菌胶囊的用药疗程,能更好重建阴道微生态,减少BV的复发。Objective To observe the effects of two kinds of treatment plan of Lactobacillus DM8909 combined with metronidazole in the treatment of bacterial vaginosis(BV)with recurrent risk factors.Methods A total of 120 cases of BV with recurrence risk factors were selected from January 2022 to January 2023 in Hospital of Chengdu University of Traditional Chinese Medicine.The enrolled patients were randomly divided into an experimental group(n=60)and a control group(n=60).The experimental group took metronidazole tablets 0.4 g each time,twice a day for 7 consecutive days,and was given a Lactobacillus DM8909 every night for vaginal use from the 8th day for 7 consecutive days.And 3 days after the first,second and third menstrual periods,a Lactobacillus DM8909 was used every night for 10 days.The control group took metronidazole tablets 0.4 g each time,twice a day for 7 consecutive days,and at the same time was given a Lactobacillus DM8909 every night for vaginal use for 7 consecutive days.The cure rate,recurrence rate,symptom improvement and vaginal microecology recovery of BV were compared between the two groups.Results There was no significant difference in the time of disappearance of the first clinical symptoms between the two groups(P>0.05).The cure rate of BV and the recovery of vaginal microecology at 1 month after treatment were slightly better in the experimental group than those in the control group,but the differences were not statistically significant(P>0.05).At 3 months,6 months and 1 year after treatment,the recurrence rate of BV in the experimental group was lower than that in the control group,and the recovery of vaginal microecology was better than that in the control group(P<0.05).The negative conversion rate of human papillomavirus(HPV)or sexually transmitted disease(STD)1 year after treatment in the experimental group was higher than that in the control group(P<0.05).Conclusion The sequential therapy of metronidazole and Lactobacillus DM8909 is slightly better than the combined therapy in the treatment of

关 键 词：细菌性阴道病 阴道乳杆菌活菌胶囊 危险因素 甲硝唑 

分 类 号：R711.3[医药卫生—妇产科学]