A double-network porous hydrogel based on high internal phase emulsions as a vehicle for potassium sucrose octasulfate delivery accelerates diabetic wound healing  

作　　者：Zhiwei Wang Lingshun Sun Weixing Wang Zheng Wang Ge Shi Honglian Dai Aixi Yu 

机构地区：[1]Department of Orthopedics Trauma and Microsurgery,Zhongnan Hospital of Wuhan University,Wuhan 430070,China [2]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Biomedical Materials and Engineering Research Center of Hubei Province,Wuhan University of Technology,Wuhan 430070,China

出　　处：《Regenerative Biomaterials》2024年第4期82-97,共16页再生生物材料（英文版）

基　　金：supported by the National Key Research and Development Program of China(2022YFB4601402);the National Natural Science Foundation of China(32201109,51772233,82072446);the Guangdong Basic and Applied Basic Research Foundation(2022B1515120052,2021A1515110557);the Key Basic Research Program of Shenzhen(JCYJ20200109150218836);the Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory(HJL202202A002);the Trauma Microsurgery Clinical Medical Research Center of Hubei Province and the Health Commission of Hubei Province Medical Leading Talent Project(LJ20200405).

摘　　要：Diabetic wounds are a difficult medical challenge.Excessive secretion of matrix metalloproteinase-9(MMP-9)in diabetic wounds further degrades the extracellular matrix and growth factors and causes severe vascular damage,which seriously hinders diabetic wound healing.To solve these issues,a double-network porous hydrogel composed of poly(methyl methacrylate-co-acrylamide)(p(MMA-co-AM))and polyvinyl alcohol(PVA)was constructed by the high internal phase emulsion(HIPE)technique for the delivery of potassium sucrose octasulfate(PSO),a drug that can inhibit MMPs,increase angiogenesis and improve microcirculation.The hydrogel possessed a typical polyHIPE hierarchical microstructure with interconnected porous morphologies,high porosity,high specific surface area,excellent mechanical properties and suitable swelling properties.Meanwhile,the p(MMA-co-AM)/PVA@PSO hydrogel showed high drug-loading performance and effective PSO release.In addition,both in vitro and in vivo studies showed that the p(MMA-co-AM)/PVA@PSO hydrogel had good biocompatibility and significantly accelerated diabetic wound healing by inhibiting excessive MMP-9 in diabetic wounds,increasing growth factor secretion,improving vascularization,increasing collagen deposition and promoting re-epithelialization.Therefore,this study provided a reliable therapeutic strategy for diabetic wound healing,some theoretical basis and new insights for the rational design and preparation of wound hydrogel dressings with high porosity,high drug-loading performance and excellent mechanical properties.

关 键 词：high internal phase emulsions double-network porous hydrogel drug delivery diabetic wound healing sucrose octasulfate 

分 类 号：TQ427.26[化学工程] R587.1[医药卫生—内分泌]