基于数理法分类的寒热并用型咳嗽中成药组方特点及临床应用  

Prescription characteristics and clinical applications of Chinese patent medicine for cough with both cooling and warming properties based upon mathematical classification

作　　者：李蒙蒙 闫红敏 罗春梅 金锐 LI Mengmeng;YAN Hongmin;LUO Chunmei;JIN Rui(Department of Pharmacy,Henan No.3 Provincial People’s Hospital,Henan Zhengzhou 450000,China;Department of Pharmacy,Second Affiliated Hospital,Army Medical University,Chongqing 400037,China;Department of Pharmacy,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]河南省直第三人民医院药学部,河南郑州450000 [2]陆军军医大学第二附属医院药剂科,重庆400037 [3]中国中医科学院西苑医院药学部,北京100091

出　　处：《中国医院药学杂志》2024年第18期2141-2145,共5页Chinese Journal of Hospital Pharmacy

基　　金：首都卫生发展科研专项(编号:首发2020-2-2081)。

摘　　要：目的:研究寒热并用型咳嗽中成药组方和性效特点,为临床合理用药、处方审核点评和药品综合评价提供依据。方法:从国家医保目录项下“止咳化痰平喘药”中,分别以药性理论为依据采用“三分运算法”并以说明书功能主治为依据采用“九宫格法”筛选寒热并用型咳嗽中成药,两者交集为最终遴选药品,分析组方与性效特点。结果:筛选得到治疗咳嗽类中成药75种,运用“三分运算法”“九宫格法”分别得到寒热并用型咳嗽中成药28种和22种,两者交集为12种,如杏贝止咳颗粒、苏黄止咳胶囊、咳喘顺丸、蛤蚧定喘丸、小儿麻甘颗粒、宣肺止嗽合剂等。这12种中成药大多含有前胡-苦杏仁、麻黄-石膏等寒热并用药对,其说明书功能主治也未标明寒热属性或标有“表寒里热”等复杂证型。结论:寒热并用型咳嗽中成药有其组方特点,往往用于寒热夹杂型咳嗽或寒热属性不明显的咳嗽,在适应证审核或联合用药点评时应予以注意。OBJECTIVE To screen Chinese patent medicine for cough with both cooling and warming properties by mathematical method and explore the characteristics of efficacy to provide theoretical rationales for rational drug uses and drug utilization evaluations at medical institutions.METHODS All expectorant and antitussive Chinese patent medicines were retrieved from National Medical Insurance Catalogue.“Tripartite algorithm” was utilized based upon drug property theory and "nine-grid" employed by major indications of the instructions for screening Chinese patent medicines with both cooling and warming property.The drugs included in both methods were the final selected drugs and their prescriptions and applications analyzed.RESULTS The authors obtained 75 species of Chinese patent medicine for cough:28 species via “Tripartite algorithm”,22 species by “ninegrid” and 12 species overlapped:Xingbei Zhike Granules,Suhuang Zhike Capsules,Kechuanshun Pill,Gejie Dingchuan Pill,Xiao'er Magan Granules and Xuanfei Zhisou Mixture.Most of them included Peucedanum root-semen armeniacae amarae,Ephedra-Gypsum and other cooling-warming drug combinations.The instructions did not distinctly specify the characteristics of “external cold & internal heat”.Chinese patent medicines with both cooling and warming property are routinely applied for coughs mixing cold and heat distinctly or indistinctly.It should be stressed during the evaluations of indications and combination medications.CONCLUSION The characteristics and clinical applications of Chinese patent medicines for cough with both cooling and warming property are summarized.It provides references for rational uses and utilization evaluations of these drugs.

关 键 词：咳嗽 中成药 寒热并用 数理方法 药学评价 处方审核 

分 类 号：R285.1[医药卫生—中药学] R925[医药卫生—中医学]