配药机器人相比人工调配对静脉药物成品输液物理稳定性的影响  

Effect of dispensing robot versus manual adjustment on the quality of intravenous infusion

作　　者：耿魁魁 何娟 苏丹 史天陆 GENG Kuikui;HE Juan;SU Dan;SHI Tianlu(Department of Pharmacy,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Anhui Hefei 230001,China;Anhui Provincial Key Laboratory of Precision Pharmaceutical Preparations and Clinical Pharmacy,Anhui Hefei 230001,China;Health Management Center,First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Anhui Hefei 230001,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)药学部,安徽合肥230000 [2]精准药物制剂与临床药学安徽省重点实验室,安徽合肥230000 [3]中国科学技术大学附属第一医院(安徽省立医院)健康管理中心,安徽合肥230000

出　　处：《中国医院药学杂志》2024年第18期2171-2178,共8页Chinese Journal of Hospital Pharmacy

基　　金：中国科学技术大学附属第一医院药剂科药学科研探索基金(编号:YJKJJ04);安徽省卫生健康科研项目基金(编号:AHWJ2023BAc20143)。

摘　　要：目的:考察配药机器人相比人工调配对静脉药物成品输液物理稳定性的影响。方法:选择溶解难易程度不同的两种常用静脉注射药物,考察调配后8 h内成品输液的微粒值、pH值、渗透压、浊度、丁达尔现象,比较配药机器人和人工调配的成品输液物理稳定性。结果:对于易溶解的药物注射用泮托拉唑钠,配药机器人调配后成品输液微粒值、pH值、渗透压、浊度和丁达尔现象与人工调配相比,差异无显著性(P>0.05),两种调配方式调配后成品输液稳定。对于难溶解的药物注射用头孢哌酮钠舒巴坦钠,配药机器人调配后成品输液4 h内粒径≥10μm、≥25μm微粒值均大于人工调配,并有统计学差异(P<0.05);渗透压方面两种调配方式无差异(P>0.05),8 h内变化均小于10%;浊度方面两种调配方式对比无统计学差异(P>0.05),且调配后8 h内浊度与0 h比较变化值均小于0.5 NTU,成品输液稳定;丁达尔现象方面,两种调配方式对比无统计学差异;pH值方面两种调配方式无差异(P>0.05),调配后成品输液8 h内变化均小于10%;调配效率方面,配药机器人优于人工调配。结论:对于易溶解的药物泮托拉唑钠,配药机器人调配的成品输液物理稳定性与人工调配无差异;但对于难溶解的药物头孢哌酮钠舒巴坦钠,人工使用振荡器调配的成品输液微粒少于配药机器人调配的成品输液,其他参数无差异,成品输液均保持稳定。医疗机构使用配液机器调配相对难溶解药物时,应评估药物的溶解程度,并优化调配步骤,以保证成品输液质量。OBJECTIVE To explore the effect of dispensing robot versus manual dispensing on the physical stability of intravenous drug infusion.METHODS Two commonly employed intravenous drugs were selected.And physical stability of finished infusion by dispensing robot versus manual dispensing was compared through examining particle value,pH value,osmotic pressure,turbidity and Tyndall phenomenon within 8h after dispensing.RESULTS For easily dissolved pantoprazole sodium for drug injection,no significant difference(P>0.05) in particle value,pH value,osmotic pressure,turbidity and Dundar phenomenon and finished product infusion remained stable after two dispensing methods.For insoluble cefoperazone sodium and sulbactam sodium for drug injection,particle size ≥ 10 μm,≥ 25 μm within 4 h after robot dispensing was greater than manual dispensing and there were significant differences(P<0.05).No difference(P>0.05) existed in osmotic pressure between two methods and change in 8 h was <10%.In terms of turbidity,there was no significant difference(P>0.05) between two methods and the change of turbidity between 8 h after blending and 0h was <0.5 NTU and finished product stablized after infusion.No significant difference existed in Tyndall phenomenon between two methods.There was no difference(P>0.05) in pH value between two methods and the change of finished product was <10% within 8h after preparation.In terms of dispensing efficiency,dispensing machine was superior to manual dispensing.CONCLUSION For easily dissolved pantoprazole sodium,physical stability of finished infusion prepared by dispensing robot is no different from that prepared manually.However,for insoluble cefoperazone sodium and sulbactam sodium,particles of finished infusion prepared by manual oscillator are worse than those prepared by dispensing robot.Other parameters of pH value,osmotic pressure,turbidity and Tyndall phenomenon show no difference between two preparations and finished infusions remain stable.Therefore,when medical institutions use liquid dispe

关 键 词：静脉用药调配中心 配药机器人 人工调配 成品输液质量 

分 类 号：R952[医药卫生—药学]