巴氯芬致慢性肾病患者癫痫持续状态1例  

Baclofen-induced status epilepticus in a patient with chronic kidney disease

作　　者：郭珮 石雪萍 邹黎 徐兴星 刘滢 GUO Pei;SHI Xueping;ZOU Li;XU Xingxing;LIU Ying(Department of Pharmacy,The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College,Chongqing 400060,China;Training Center,Chongqing Medical and Pharmaceutical College,Chongqing 401331,China;Department of Basic Medical Science,Chongqing Three Gorges Medical College,Chongqing 404120,China)

机构地区：[1]重庆医药高等专科学校附属第一医院药学部,重庆400060 [2]重庆医药高等专科学校实训中心,重庆401331 [3]重庆三峡医药高等专科学校基础医学部,重庆404120

出　　处：《中国医院药学杂志》2024年第18期2192-2194,共3页Chinese Journal of Hospital Pharmacy

摘　　要：1例75岁患者因慢性肾病5期长期血液透析,入院后因呃逆服用巴氯芬,未减量。第1次服药后患者出现眩晕和抽搐加重,第4次服药后出现意识障碍,临床考虑巴氯芬导致并进行血液灌流。血液灌流过程中出现癫痫样症状合并持续失神状态,动态脑电图提示癫痫,最终判断为巴氯芬导致的毒性代谢性脑病、癫痫持续状态。经持续血液透析,患者意识恢复、癫痫控制后出院。A 75-year-old patient with stage 5 chronic kidney disease on long-term dialysis took normal dose of baclofen for hiccup after admission.After the first dose of baclofen,the patient experienced increased dizziness and convulsions,and after the fourth dose,the patient developed consciousness disorders.The doctor considered that the patient's condition was directly linked to baclofen intake,necessitating immediate blood perfusion treatment.During the process of blood perfusion,the patient presents with epilepsy like symptoms combined with persistent absence,and the dynamic electroencephalogram indicates epilepsy.In this case,we believe that the condition is toxic metabolic encephalopathy and status epilepticus triggered by baclofen.After continuous hemodialysis,the patient regained consciousness and was discharged after epilepsy control.

关 键 词：巴氯芬 毒性代谢性脑病 癫痫持续状态 慢性肾病 

分 类 号：R969.3[医药卫生—药理学]