Green synthesis of biocompatible Gd^(3+)-doped ultrasmall carbon-based nanohybrids from coffee wastes  

作　　者：Konstantin Paliienko Anna Topchylo Sergei Alekseev Alain Géloën Yurii Milovanov Tetiana Lysenko Valeriy Skryshevsky Tatiana Borisova Vladimir Lysenko 

机构地区：[1]Department of Neurochemistry,Palladin Institute of Biochemistry,National Academy of Sciences of Ukraine,9 Leontovicha str,Kyiv 01054,Ukraine [2]Corporation Science Park,Taras Shevchenko University of Kyiv,60 Volodymyrska Str.,Kyiv 01033,Ukraine [3]Institute of High Technologies,Taras Shevchenko National University of Kyiv,64 Volodymyrska Str.,01601 Kyiv,Ukraine [4]Faculty of Chemistry,Taras Shevchenko National University of Kyiv,64 Volodymyrska Str.,01601 Kyiv,Ukraine [5]UMR Ecologie Microbienne Lyon(LEM),CNRS 5557,INRAE 1418,Claude Bernard University of Lyon,VetAgro Sup,Research Team“Bacterial Opportunistic Pathogens and Environment”(BPOE),University of Lyon,F-69622 Villeurbanne,France [6]Light Matter Institute,UMR-5306,Claude Bernard University of Lyon/CNRS,Universitéde Lyon,69622 Villeurbanne Cedex,France

出　　处：《Carbon Resources Conversion》2024年第2期64-73,共10页碳资源转化（英文）

基　　金：the support of EU Horizon 2020 Research and Innovation Staff Exchange Programme(RISE)under Marie Skłodowska-Curie Action(project 101008159“UNAT”).

摘　　要：A cheap method allowing fabrication of biocompatible,ultra-small(2-10 nm)and fluorescent(λ_(em)=425-500 nm)nanohybrids(NHs)from coffee wastes is reported.The gadolinium-doped nanohybrids(GDNHs)or gadolinium-free carbon dots(GFCDs)can be synthesized in a domestic microwave oven according to green synthesis principles.Hydrodynamic sizes,chemical composition,impact on proton magnetic resonance relaxation time and optical properties of the GDNHs and GFCDs were studied in details and compared.In particular,doping of the NHs with Gd^(3+)ions,up to 1.87%w/w of gadolinium per particles’weight,will allow their application for magnetic resonance imaging(MRI).Furthermore,cell culture tests on human adenocarcinomic alveolar basal epithelial cells line(A549)have shown high biocompatibility of the GDNHs and in a wide concentration range 100-1000μg/ml.

关 键 词：Carbon dots from coffee waste Carbon dots for MRI Gadolinium-doped carbon dots Microwave-assisted synthesis 

分 类 号：TB383[一般工业技术—材料科学与工程]