淫羊藿类黄酮生物合成相关基因研究进展  

Research Progress on Genes Related to Flavonoids Biosynthesis in Herba Epimedii

作　　者：范雪兰 落艳娇 徐超群 郭宝林[1] Xuelan Fan;Yanjiao Luo;Chaoqun Xu;Baolin Guo(Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicines,Ministry of Education,Institute of Medicinal Plant Development,Peking Union Medical College&Chinese Academy of Medical Sciences,Beijing 100193,China;Jiangxi University of Chinese Medicine,Nanchang 330000,China;Institute of Traditional Chinese Medicine Health Industry,China Academy of Chinese Medical Sciences,Nanchang 330000,China)

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,中草药物质基础与资源利用教育部重点实验室,北京100193 [2]江西中医药大学,南昌330000 [3]中国中医科学院中医药健康产业研究所,南昌330000

出　　处：《植物学报》2024年第5期834-846,共13页Chinese Bulletin of Botany

基　　金：中国医学科学院医学与健康科技创新工程(No.2021-I2M-1-031)。

摘　　要：淫羊藿(Herba Epimedii)是一种历史悠久的中草药(TCM),药用价值高,国内淫羊藿相关研究备受关注。黄酮醇苷类(PFGs)成分是淫羊藿的主要活性物质,其含量决定了药用品质。了解淫羊藿类黄酮生物合成途径,挖掘与淫羊藿黄酮醇苷类含量相关的基因,阐明其生物合成途径的调控机制对于提高淫羊藿品质至关重要。该文系统综述了淫羊藿类黄酮生物合成相关结构基因和转录因子基因研究进展,为揭示黄酮含量的分子调控机制,进而为淫羊藿分子育种和黄酮醇苷的合成生物学研究奠定理论基础。Herba Epimedii is a traditional Chinese herb medicine(TCM)with a long history.Research on Herba Epimedii has attracted much attention in China due to its high medicinal value.C8-prenylated flavonol glycosides(PFGs)have been demonstrated to be the main bioactive components in Epimedium brevicornu,and their content determines the medicinal quality.Understanding the biosynthesis pathway of PFGs,exploring genes related to PFGs content,and elucidating the regulatory mechanisms of PFGs biosynthesis pathway is fundamental and essential for improving the quality of E.brevicornu.Here,we provide a comprehensive review of the research on structural and transcriptional factor genes related to the biosynthesis of PFGs,which not only contributes to unravel the regulatory mechanisms related to PFGs content,but also lay a foundation for research on molecular breeding and the synthetic biology in Epimedium plants.

关 键 词：淫羊藿 黄酮醇苷 生物合成 结构基因 调控基因 

分 类 号：S567[农业科学—中草药栽培]