PET/CT诊断药物^(68)Ga-FAPI-04的应用进展  

Progress in the application of PET/CT diagnostic drug^(68)Ga-FAPI-04

作　　者：李攀峰 于江[2] 侯文彬 李祎亮 Li Panfeng;Yu Jiang;Hou Wenbin;Li Yiliang(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,State Key Laboratory of Advanced Medical Materials and Devices,Tianjin Institutes of Health Science,Institute of Radiation Medicine,Chinese Academy of Medical Science and Peking Union Medical College,Tianjin 300192,China)

机构地区：[1]天津中医药大学研究生院,天津301617 [2]中国医学科学院北京协和医学院放射医学研究所,天津市放射医学与分子核医学重点实验室,先进医用材料与医疗器械全国重点实验室,天津市医学健康研究院,天津300192

出　　处：《国际放射医学核医学杂志》2024年第7期455-461,共7页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：中国医学科学院医学与健康科技创新工程国家医学健康科技战略平台与体系建设专项(2022-I2M-2-003)。

摘　　要：成纤维细胞活化蛋白(FAP)是一种Ⅱ型膜结合糖蛋白,其在90%的上皮肿瘤、伤口愈合或炎症部位的成纤维细胞中过表达,而在正常组织中低表达或不表达,是疾病诊疗的重要靶点之一。^(68)Ga-FAPI-04是基于喹啉类FAP抑制剂开发的PET诊断药物,在患者体内外均表现出对FAP的高度特异性与亲和力,在基础研究及临床应用中均得到广泛关注。笔者就^(68)Ga-FAPI-04的基本概况及其在多种恶性肿瘤、非肿瘤疾病中的应用进展进行综述。Fibroblast activation protein(FAP)is a typeⅡmembrane-bound glycoprotein that is overexpressed in fibroblasts of 90%epithelial tumors,wound healing or inflammatory sites,but is low or absent in normal tissues,and is an important target for disease diagnosis and treatment.^(68)Ga-FAPI-04 is a PET diagnostic drug based on quinoline-based FAP inhibitors,which has shown high specificity and affinity for FAP in patients both in vivo and in vitro,and has received wide attention in basic research and clinical applications.The author reviewed the basic overview of^(68)Ga-FAPI-04 and its application in various malignant and non-cancerous diseases.

关 键 词：正电子发射断层显像术 体层摄影术 X线计算机 成纤维细胞活化蛋白 肿瘤 ^(68)Ga-FAPI-04 

分 类 号：R981[医药卫生—药品]