苏合香丸联合丁苯酞对急性脑梗死患者氧化应激因子、认知功能及血液流变学的影响  

The Effects of Suhexiang Pill Combined with Butylphthalein Injection on Oxidative Stress Factors,Cognitive Function and Hemorheology in Patients with Acute Cerebral Infarction

作　　者：谢晨璐 孔越 吴漫 XIE Chenlu;KONG Yue;WU Man(Jiujiang Hospital of Traditional Chinese Medicine,Jiujiang 332000,China)

机构地区：[1]九江市中医医院,江西九江332000

出　　处：《江西中医药大学学报》2024年第5期43-46,共4页Journal of Jiangxi University of Chinese Medicine

基　　金：江西省卫生健康委科技计划项目(202311586)。

摘　　要：目的:探讨苏合香丸联合丁苯酞注射液治疗急性脑梗死患者的临床疗效及对氧化应激因子、认知功能及血液流变学的影响。方法:选取九江市中医医院2022年10月—2023年10月收治的急性脑梗死患者92例,随机分为对照组和观察组,各46例。2组患者均予丁苯酞注射液治疗,观察组在对照组基础上加服苏合香丸,均连续治疗14 d。比较2组患者治疗前后全血黏度、平均纤维蛋白原、血浆黏度、红细胞比积等血液流变学指标变化,血清氧化应激因子白细胞介素-6(IL-6)、同型半胱氨酸(Hcy)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平变化,神经功能缺损程度(NIHSS)评分、蒙特利尔认知评估量表(MOCA)评分、中医证候积分变化,以及临床疗效、不良反应等。结果:与治疗前比较,2组患者治疗后全血黏度、平均纤维蛋白原、血浆黏度、红细胞比积水平和NIHSS评分、中医证候积分以及IL-6、Hcy、TNF-α、CRP水平均有下降,且观察组低于对照组;MOCA评分均有升高,且观察组高于对照组,差异均有统计学意义(P<0.05)。观察组治疗总有效率为95.77%,高于对照组的85.51%,差异有统计学意义(P<0.05)。2组不良反应发生率比较无显著性差异(P>0.05)。结论:苏合香丸联合丁苯酞注射液能够降低血清氧化应激因子水平、改善患者认知功能及血液流变学指标,可安全有效改善患者生活质量,疗效显著。Objective:To investigate the clinical efficacy of Suhexiang Pill combined with butylphthalein injection in the treatment of acute cerebral infarction and the effects on oxidative stress factors,cognitive function and hemorheology.Methods:A total of 92 patients with acute cerebral infarction admitted to Jiujiang Hospital of Traditional Chinese Medicine from October 2022 to October 2023 were randomly divided into control group and observation group,46 patients in each group.2 groups were treated with butylphthalein injection,and the observation group was treated with Suhexiang Pill on the basis of control group for 14 days.The changes of whole blood viscosity,mean fibrinogen,plasma viscosity,erythrocyte specific hydrops equal hemorheology indexes,serum levels of oxidative stress factor interleukin-6(IL-6),homocysteine(Hcy),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)were compared between the two groups before and after treatment.Neurological impairment(NIHSS)score,Montreal Cognitive Assessment Scale(MOCA)score,TCM syndrome score changes,clinical efficacy and adverse reactions of the 2 groups.Results:Compared with before treatment,whole blood viscosity,mean fibrinogen,plasma viscosity,erythrocyte specific hydrops,NIHSS score,TCM syndrome score,IL-6,Hcy,TNF-αand hs-CRP levels in 2 groups were decreased after treatment,and the observation group was lower than that in control group.MOCA scores in the observation group were higher than those in the control group,with statistical significance(P<0.05).The total effective rate of combination group was 95.77%,which was higher than 85.51%in control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion:Suhexiang Pill combined with butylphthalein injection can inhibit serum oxidative stress factors,improve cognitive function and hemorheology indexes of patients,and safely and effectively improve patients'quality of life,

关 键 词：苏合香丸 丁苯酞注射液 急性脑梗死 氧化应激 认知功能 血液流变学 

分 类 号：R255.2[医药卫生—中医内科学]