不同针灸方法对慢性疲劳综合征大鼠运动能力及细胞因子的影响  

Effect of Different Acupuncture Methods on Motor Function and Cytokines of Rats with Chronic Fatigue Syndrome

作　　者：刘长征[1] 雷波[1] LIU Changzheng;LEI Bo(Yichun University,Yichun 336000,China)

机构地区：[1]宜春学院美容医学院,江西宜春336000

出　　处：《江西中医药大学学报》2024年第5期82-84,共3页Journal of Jiangxi University of Chinese Medicine

基　　金：江西省教育厅科技项目(GJJ211636)。

摘　　要：目的:探讨不同针灸方法对慢性疲劳综合征(CFS)大鼠运动能力及细胞因子的影响。方法:64只SD大鼠随机分为空白对照组、模型组、毫针1组、毫针2组、电针1组、电针2组、艾灸1组、艾灸2组,每组8只。采用慢性多重复合应激法制备CFS大鼠模型。毫针1组、电针1组、艾灸1组选取百会、足三里(双)、三阴交(双)穴,分别采用毫针、电针、艾灸治疗,每天1次,连续治疗18 d。毫针2组、电针2组、艾灸2组操作同1组,隔天1次,连续治疗9次。治疗结束后,记录大鼠负重力竭游泳时间以测评大鼠运动能力,检测大鼠血清IL-4、IL-10、IFN-γ、TNF-α分泌水平。结果:造模完成后,模型组大鼠力竭游泳时间较空白对照组缩短(P<0.05),针灸各组治疗后大鼠力竭游泳时间均较模型组长(P<0.05),其中艾灸1组大鼠力竭游泳时间最长;模型组大鼠血清IL-4、IL-10水平较空白对照组升高,IFN-γ、TNF-α水平较空白对照组降低。针灸治疗后,各组IL-4、IL-10水平均下降,IFN-γ、TNF-α水平均上升,其中艾灸1组对IL-4、IL-10的改善优于其他治疗组。结论:毫针、电针、艾灸均可延长大鼠力竭游泳时间,调节细胞因子的分泌水平,以艾灸每日1次的效果为最佳。Objective:To study the effect of different acupuncture methods on motor function and cytokines of rats with chronic fatigue syndrome.Methods:Sixty-four SD rats were randomly divided into blank group,model group,acupuncture group 1,acupuncture group 2,electroacupuncture group 1,electroacupuncture group 2,moxibustion group 1 and moxibustion group 2.It was through chronic multiple compound stress method to set up the CFS model of rats,Acupuncture group 1,electroacupuncture group 1,moxibustion group 1,selected Baihui,Zusanli(double)and Sanyinjiao(double)points,respectively using acupuncture,electroacupuncture,moxibustion treatment,once a day for 18 days.Acupuncture group 2,electroacupuncture group 2 and moxibustion group 2 were the same as group 1,once every other day for 9 treatments.After the treatment,detect motor function of the rats and the serum secretion levels of IL-4、IL-10、IFN-γ、TNF-α.Results:Exhaustion swimming time in the model group was shorter than blank group(P<0.05),each group after treatment was longer than the model group(P<0.05),among them,moxibustion group 1 is the longest;the levels of IL-4 and IL-10 in the model group is increased and the levels of IFN-γand TNF-αis decreased than the blank group.After treatment,the levels of IL-4 and IL-10 decreased and the levels of IFN-γand TNF-αincreased in all groups,moxibustion group 1 improved IL-4 and IL-10 better than the other treatment groups.Conclusion:Acupuncture,electroacupuncture and moxibustion can improve the motor function and immune function of CFS rats,among which,moxibustion once a day has the best effect.

关 键 词：毫针 电针 艾灸 慢性疲劳综合征 细胞因子 

分 类 号：R245[医药卫生—针灸推拿学]