抗菌肽LL-37胞内诱导表达机制的研究进展  

Research progress on the mechanism of intracellular-induced expression of antimicrobial peptide LL-37

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作  者:张孟捷 李晓飞 李云露 焦新安 黄金林[1,2,3,4] ZHANG Mengjie;LI Xiaofei;LI Yunlu;JIAO Xin'an;HUANG Jinlin(Jiangsu Key Laboratory of Zoonosis,Yangzhou University,Yangzhou 225009,Jiangsu,China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou 225009,Jiangsu,China;Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agrifood Safety and Quality,Ministry of Agriculture and Rural Affairs,Yangzhou 225009,Jiangsu,China;Joint International Research Laboratory of Agriculture and Agri-Product Safety,Ministry of Education,Yangzhou 225009,Jiangsu,China)

机构地区:[1]扬州大学,江苏省人兽共患病学重点实验室,江苏扬州225009 [2]江苏高校动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009 [3]农业农村部农产品质量安全生物性危害因子(动物源)控制重点实验室,江苏扬州225009 [4]教育部农业与农产品安全国际合作联合实验室,江苏扬州225009

出  处:《微生物学报》2024年第10期3647-3655,共9页Acta Microbiologica Sinica

基  金:国家自然科学基金(32172939);扬州大学兽医学学科特区学科交叉课题支持项目(yzuxk202003);扬州市重点研发计划(社会发展)(YZ2022059);山东省泰山产业领军人才项目(tscy20190113)。

摘  要:先天免疫是免疫防御的第一道防线,抗菌肽LL-37作为人体先天免疫的一部分,在维持人体稳态中发挥重要作用,具备直接杀菌和免疫调节两大功能。目前,对LL-37的研究主要侧重于其功能本身,而对其在体内的诱导表达知之甚少。然而,这对深入探究人体免疫防御机制至关重要。因此,本文简要综述了LL-37的合成过程与功能、诱导分泌的因素以及诱导表达的调控通路等方面的研究进展,旨在为进一步揭示LL-37在人体内的调控通路及免疫防御功能提供新思路。Innate immunity constitutes the first line of immune defense.As a part of the body's innate immunity,the antimicrobial peptide LL-37 plays a crucial role in maintaining homeostasis,with two primary functions:direct antimicrobial activity and immunomodulation.Currently,research on LL-37 mainly focuses on its function,while its induced expression in vivo has rarely been studied.However,understanding the induced expression of LL-37 is essential for delving into the body's immune defense mechanisms.Therefore,this paper briefly reviewed the research progress on the synthesis and functions of LL-37,the factors inducing its secretion,and the regulatory pathways involved in its induced expression.The aim is to offer new insights into the regulatory pathways and immune defense functions of LL-37 in the human body.

关 键 词:抗菌肽LL-37 体内诱导 调控通路 

分 类 号:R392[医药卫生—免疫学]

 

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