麒麟丸联合精囊镜技术治疗射精管梗阻少弱精症的临床疗效  

Qilin pills combined with transurethral seminal vesiculoscopy in the treatment of oligoasthenozoospermia secondary to ejaculatory duct obstruction:a clinical observation

作　　者：王锋锋 李虎 苏孟媛 苏嘉明 何祖强 钟自强 蒋斌 王永兴 Wang Fengfeng;Li Hu;Su Mengyuan;Su Jiaming;He Zuqiang;Zhong Ziqiang;Jiang Bin;Wang Yongxing(Department of Urology,Guangzhou Baiyum District Maternal and Child Health Hospital,Guangzhou,Guangdong 510410,China)

机构地区：[1]广州市白云区妇幼保健院泌尿男科,广东广州510410

出　　处：《泌尿外科杂志（电子版）》2024年第3期37-42,共6页Journal of Urology for Clinicians(Electronic Version)

摘　　要：目的分析麒麟丸联合精囊镜技术在治疗射精管梗阻(ejaculatory duct obstruction,EDO)少弱精症患者的可行性和有效性。方法选取2016年6月至2022年5月广州市白云区妇幼保健院收治的46例EDO患者作为研究对象,按就诊顺序随机分为对照组和观察组,每组23例,均接受精囊镜手术,其中,观察组患者于术后第1天开始口服麒麟丸治疗,连续服用6个月。观察两组患者术前和术后第1、3、6个月的精液量、精子密度、前向运动精子比例、精浆果糖和精浆α-葡萄糖苷酶等指标变化,同时随访记录其配偶术后第3、6、12个月内的自然妊娠率。结果所有患者均顺利完成手术,两组在手术时间、住院天数、入镜方式、梗阻程度和并发症方面差异均无统计学意义(P>0.05)。两组患者术后6个月复查精液量、精子密度、前向运动精子比例、精浆果糖、精浆α-葡萄糖苷酶均优于术前,差异有统计学意义(P<0.05)。组间比较,两组患者术后第1、3、6个月的精液量和精浆α-葡萄糖苷酶差异均无统计学意义(P<0.05)。观察组术后6个月的精子密度、前向运动精子比例、精浆果糖及精浆α-葡萄糖苷酶均显著优于对照组(P<0.05),观察组术后第6、12个月配偶自然妊娠数高于同时期对照组(P<0.05)。结论精囊镜技术是治疗EDO的一种有效、安全且微创的内镜技术,麒麟丸联合精囊技术可进一步改善EDO患者术后的精液质量,并提高配偶妊娠率。Objective To analyze the feasibility and effect of the combination of Qilin pills and the technique of transurethral seminal vesiculoscopy in the treatment of the patients with oligoasthenozoospermia secondary ejaculatory duct obstruction(EDO).Methods A total of 46 patients with servere oligoasthenozoospermia secondary ejaculatory to duct obstruction that treated in Guangzhou Baiyun District Maternal and Child Health Hospital from June 2016 to May 2022 were randomly divided into control group and observation group,23 patients in each group.All patients in both two groups were treated by the technique of transurethral seminal vesiculoscopy.The observation group also took Qilin pills at the dose of 6 g,twice per day,for 6 months after surgery.The semen parameters,fructose andα-glycosidase from the patients at 1,3 and 6 months after surgery were obtained and the rate of pregnancy at 3,6,12 months postoperatively were recorded.Results All patients took the operation successfully,and there were no statistically significant differences in operation time,hospital stay,method of entry,operation choice,surgical complications,and the severity of obstruction between the two groups(P>0.05).Compared with the baseline,two group of patients showed significant increases at 6 months postoperatively in semen volume,sperm density,pregnancy of progressively motile sperm,seminal fructose,andα-glycosidase(P<0.05).There were no significant differences in semen volume andα-grycosidase from the patients at 1,3 and 6 months after operation between the two groups(P>0.05).However,at 6 months,sperm density,percentage of progressively motile sperm,seminal fructose andα-glycosidase in the observation group were significantly higher than the control group(P<0.05).The rate of natural pregnancy in the observation group at 6 and 12 months after surgery was higher than that in the control group during the same period(P<0.05).Conclusions Transurethral seminal vesiculoscopy is an effective,safe and minimally invasive endoscopic technology for the

关 键 词：麒麟丸 精囊镜技术 射精管梗阻 少弱精子症 

分 类 号：R698.2[医药卫生—泌尿科学]