转录组学蛋白组学和代谢组学生物标志物与儿童肥胖研究进展  

Advances in biomarkers of transcriptomics, proteomics and metabolomics and childhood obesity

作　　者：夏志伟 沈葹 王路[1] 孙冰洁[1] 殷继永 霍军生 郭欣[1] XIA Zhiwei;SHEN Shi;WANG Lu;SUN Bingjie;YIN Jiyong;HUO Junsheng;GUO Xin(Institute of School Health,Beijing Center for Disease Control and Prevention,Beijing(100013),China;不详)

机构地区：[1]北京市疾病预防控制中心学校卫生所,100013 [2]中国疾病预防控制中心营养与健康所/国家卫生健康委公共营养与健康重点实验室

出　　处：《中国学校卫生》2024年第9期1364-1368,共5页Chinese Journal of School Health

基　　金：北京市卫生健康委员会高层次公共卫生技术人才建设项目(领军人才-01-09)。

摘　　要：组学生物标志物有助于提高人们对肥胖病因及其与慢性病联系的认识,文章概述了基于转录组学、蛋白组学、代谢组学肥胖表型生物标志物的最新进展,加深了对肥胖病因及干预效果异质性的理解;此外,将组学生物标志物应用到儿童肥胖精准防控中,不同组学生物标志物可以提高“肥胖”一词的精确度,并有助于早期检测具有风险特征的特定生物标志物,以便实现儿童肥胖从“一刀切”的防控策略转变为在肥胖发生发展过程中个性化的防治方案。Biomarkers could improve the understanding of the causes of obesity and its association with chronic diseases for people.The purpose of the review is to summarize recent advances in transcriptomic,proteomic,and metabolomic phenotypic biomarkers of obesity in order to deepen the understanding of the etiology of obesity and its metabolic consequences.In the precise prevention and control of childhood obesity,different groups of biomarkers can improve the accuracy of the word"obesity"and help early detection of specific biomarkers with risk characteristics,so as to realize the transformation of childhood obesity from a one-size-fits-all prevention and control strategy to a personalized prevention and control plan during the development of obesity.

关 键 词：基因组学 蛋白质组学 生物学标记 肥胖症 儿童 

分 类 号：R179[医药卫生—妇幼卫生保健] R723.14[医药卫生—公共卫生与预防医学] Q343.13[生物学—遗传学]