高亲水性壳聚糖纳米纤维膜的制备及性能  

Preparation and performance of highly hydrophilic chitosan nanofiber membranes

作　　者：戈亚锋 王琰 徐楚琪 JIRI Militky DANA Kremenakova 祝国成 GE Yafeng;WANG Yan;XU Chuqi;JIRI Militky;DANA Kremenakova;ZHU Guocheng(College of Textile Science and Engineering(International Institute of Silk),Zhejiang Sci-Tech University,Hangzhou 310018,China;Zhejiang-Czech Joint Laboratory of Advanced Fiber Materials,Zhejiang Sci-Tech University,Hangzhou 310018,China;Faculty of Textile Engineering,Technical University of Liberec,Liberec 46117,Czech Republic;Zhejiang Provincial Innovation Center of Advanced Textile Technology(Jianhu Laboratory),Shaoxing 312000,China)

机构地区：[1]浙江理工大学纺织科学与工程学院(国际丝绸学院),杭州310018 [2]浙江理工大学浙江-捷克先进纤维材料联合实验室,杭州310018 [3]利贝雷茨理工大学纺织工程学院,捷克利贝雷茨46117 [4]现代纺织技术创新中心(鉴湖实验室),浙江绍兴312000

出　　处：《现代纺织技术》2024年第10期11-19,共9页Advanced Textile Technology

基　　金：浙江省“尖兵”“领雁”研发攻关计划项目(2023C01194);高等学校学科创新引智计划资助项目(D21011)。

摘　　要：为满足医用创伤敷料对高亲水性和抑菌性的要求,以壳聚糖(CS)、聚乙烯醇(PVA)、甘油(GL)为原料,通过静电纺丝技术制备了PVA/CS/GL纳米纤维膜。对纳米纤维膜的形貌和结构进行表征,分析其热稳定性、亲水性、溶胀度和力学性能,并探究其抗菌性能。结果表明:当甘油质量分数为3%时,PVA/CS/GL纳米纤维膜综合性能最佳,具有较好的网状结构和均匀的纤维直径,其中甘油的添加改善了壳聚糖基纳米纤维膜亲水性差、力学强度低等不足。当加入质量分数为3%的甘油后,纳米纤维膜的接触角从53.3°降低至25.3°,在PBS缓冲液中的平衡溶胀率从239.5%提高到332.1%,拉伸强度和断裂伸长率分别从2.68 MPa、8.2%提升到5.83 MPa、17.9%。抗菌实验表明,PVA/CS/GL纳米纤维膜对大肠杆菌和金黄色葡萄球菌的抑菌率分别为94.39%、89.65%,表现出良好的抑菌效果。因此,该PVA/CS/GL纳米纤维膜在医用创伤敷料方面具有潜在应用价值。Medical dressings are a common medical device playing a significant role in the medical realm.It has a wide range of applications in the treatment healing and infection control of trauma and surgical wounds.Research has found that wounds can heal better and faster in a moist environment.Hence an ideal medical dressing should maintain optimal moisture levels at the wound site and effectively absorb exudates.Serving as a barrier against microorganisms medical dressings must possess robust mechanical properties flexibility to conform to diverse wound shapes and effective antibacterial qualities to expedite the healing process.Electrospinning a technique that utilizes a high-voltage electrostatic field to produce ultrafine fibers has attracted much attention due to the highly similar structure of the nanofiber membrane to the natural extracellular matrix of the human body.Electrospinning usually uses natural or synthetic polymer materials as raw materials most of which have good biocompatibility can be compatible with human tissues and reduce allergic reactions to patients.By modifying the membrane's surface adjusting the electrospun material or incorporating drugs we can create specialized functional dressings tailored to diverse application scenarios thus offering convenience to both medical professionals and patients Consequently further investigation and utilization of nanofiber membrane medical dressings hold substantial clinical importance and promise for the future Chitosan CS a multifunctional biomaterial is renowned for its non-toxicity biodegradability and excellent biocompatibility.In addition materials based on CS also have immune stimulation and antibacterial performance and are often used in fields such as wound healing hemostasis tissue engineering and medical textiles.Nonetheless CS suffers from poor electrospinning performance and insufficient mechanical strength often necessitating crosslinking or blending with other polymers to enhance these properties.Polyvinyl alcohol PVA a water-soluble polymer

关 键 词：壳聚糖 聚乙烯醇 甘油 纳米纤维膜 亲水性 溶胀性 

分 类 号：TQ340.64[化学工程—化纤工业]