静电纺丝纳米纤维在药物输送领域的应用  

Research on the application of electrospinning nanofibers in the field of drug delivery

作　　者：杨海贞 魏肃桀 马闯 周泽林 胡亚雯 YANG Haizhen;WEI Sujie;MA Chuang;ZHOU Zein;HU Yawen(College of Textiles,Zhongyuan University of Technology,Zhengzhou 450007,China)

机构地区：[1]中原工学院纺织学院,郑州450007

出　　处：《现代纺织技术》2024年第10期56-67,共12页Advanced Textile Technology

基　　金：河南省科技攻关项目(222102230065);中原工学院青年人才创新能力基金项目(K2020QN003);国家级大学生创新创业训练计划项目(202210465036,202310465017);中国纺织工业联合会科技指导性计划项目(2021043);河南省大学生创新创业训练计划项目(202410465024,202410465026)。

摘　　要：药物输送系统能够最大限度地提高递送药物的治疗效果,并减少副作用,引起了研究者的广泛关注。随着患者治疗需求的不断增加,传统药物输送方法无法充分适应患者体内的需求。而基于静电纺丝纳米纤维的给药系统具有高比表面积、可调节孔隙率、良好的机械耐久性、药物包封性、生物相容性和高缓释性能,为药物载量和可定制释放特性提供了兼容的环境。通过对静电纺丝原理以及药物封装方法的阐述,体现了静电纺丝纳米纤维膜作为新兴药物输送载体的独特优势,同时探究了不同种类的载药纳米纤维膜在未来应用中的可能性。分析结果表明,通过静电纺丝法可以制备出不同形貌结构的纳米纤维,并通过合理结构设计可以调控药物在体内的释放行为和效率。因此,将载药纳米纤维功能化,可以得到具有药物缓释、抗菌、消炎等性能的药物输送系统,可为解决某些药物应用困难、收效甚微的难题提供新的途径。Electrospun nanofibers have the characteristics of extremely fine diameter high specific surface area and good pore structure.They are easy to operate low costing and mass-producible.Their unique structure and performance have received widespread attention in the field of drug delivery.In recent years the application of electrospun nanofibers in the field of drug delivery has made further research breakthroughs.By controlling the diameter and shape of the fibers efficient drug loading and sustained release can be achieved and drug bioavailability and reducing toxic side effects can be enhanced.These properties expedite the application prospects of electrospun nanofibers in drug delivery.In recent years electrospun nanofibers have been widely used in the field of drug delivery.Their nanoscale diameter and porous structure make electrospun nanofibers an ideal drug carrier material.Biodegradable polymer nanofiber membranes can not only stably carry various types of drugs but also achieve slow drug release thereby improving drug efficacy and reducing side effects.Compared to traditional drug delivery systems electrospun nanofibers have many advantages.Firstly their nanoscale diameter and porous structure are beneficial for improving the solubility and bioavailability of drugs enhancing their stability and bioavailability efficiency.Secondly electrospun nanofibers can simulate the natural extracellular matrix structure provide a scaffold for cell adhesion and help promote tissue regeneration and healing.In addition electrospun nanofibers can also achieve controlled drug release further improving the therapeutic effect of drugs.Research and development based on pharmaceutical technology is the foundation for enhancing the development of drug delivery.Research has confirmed that electrospun nanofibers as drug carriers have become a hot research topic in the field of drug delivery for local drug delivery and slow release drug systems in the treatment of diseases.By encapsulating drugs within electrospun nanofibers not on

关 键 词：静电纺丝 药物输送 抗癌症 抗感染 非甾体类抗炎药 组织工程 

分 类 号：TS199[轻工技术与工程—纺织化学与染整工程]