基于钙吸收的几种有机钙盐溶解度的研究进展  

Research on the Solubility of Several Organic Calcium Salts Based on Calcium Absorption

作　　者：陆芳芳 仇立志 于钦云 李树英 段洪东[2] Lu Fangfang;Qiu Lizhi;Yu Qinyun;Li Shuying;Duan Hongdong(Enterprise Technology Center of Qingdao Double Whale Pharmaceutical Co.,Ltd.,Qingdao 266109,China;College of Chemistry and Chemical Engineering,Qilu University of Technology,Jinan 250012,China)

机构地区：[1]青岛双鲸药业股份有限公司企业技术中心,山东青岛266109 [2]齐鲁工业大学化学与化工学院,山东济南250012

出　　处：《山东化工》2024年第18期109-113,129,共6页Shandong Chemical Industry

摘　　要：有机钙是钙补充剂中重要的钙源形式,是由有机化合物与无机钙离子以离子键或配位键结合而成的化合物。相对于无机钙,有机钙更易溶于水,在溶解的过程中不需要胃酸的参与,对胃肠刺激较小,但部分有机钙的溶解度直接影响钙制剂吸收及稳定性,过饱和钙盐制剂在放置过程中易析出固体,直接影响药品稳定性及有效性。基于影响钙吸收代谢的主要因素,针对几种常见有机钙盐的溶解度及不同增溶方式进行了系统调研,以便为开发系列有机钙盐药品提供技术支持。As an important form of calcium source in calcium supplements,organic calcium is a type of compound formed by the combination of organic compounds and inorganic calcium ions through ionic bonds or coordination bonds.Organic calcium is more soluble in water than inorganic calcium,it does not require gastric acid during the dissolution process and has less gastrointestinal irritation.However,the solubility of some organic calcium directly affects the absorption and stability of calcium preparations,especially the phenomenon of supersaturation in some organic calcium salt medicines,and solids are easy to precipitate during the placing process,which directly affects the stability and effectiveness of the medicines.Based on the main factors that affect calcium absorption and metabolism,this article systematically investigates the solubility of several common organic calcium salts and different solubilization methods in order to provide technical support for the development of a series of organic calcium salt drugs.

关 键 词：有机钙 吸收 溶解度 增溶 

分 类 号：O614.231[理学—无机化学]