中药物质基础新形式及其药动/药效研究  

New Forms of Material Basis for Traditional Chinese Medicine and Their Pharmacokinetics/Pharmacodynamics Study

作　　者：惠璇 张竞研 康安[2] 张经纬[1] 王广基[1] HUI Xuan;ZHANG Jingyan;KANG An;ZHANG Jingwei;WANG Guangji(Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics,Research Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical Sciences,China Pharmaceutical University,Nanjing 210009,China;School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]中国药科大学江苏省药物代谢动力学研究重点实验室,中国医学科学院“中药复杂组分PK-PD结合研究”创新单元,江苏南京210009 [2]南京中医药大学药学院,江苏南京210023

出　　处：《南京中医药大学学报》2024年第10期1013-1023,共11页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：中国医学科学院医学与健康科技创新工程项目(2021-I2M-5-011)。

摘　　要：中药作为中华民族的瑰宝,拥有悠久的历史和丰富的文化内涵。过去几百年,大量结构明确、活性显著、机制清楚的活性化合物被发现,其研究初步明晰了中药的效应物质基础。然而,中药的天然成分具有骨架多样性和结构复杂性,除了单体小分子化合物,近年来越来越多的研究发现中药存在发挥药效的物质基础新形式,如活性单体化合物形成的超分子,以及具有药理活性的生物大分子等。聚焦中药物质基础新形式,通过新技术、新机制、新应用的分析,以期为中药药效物质基础、药动/药效相关性研究提供新思路。Traditional Chinese medicine,as a treasure of the Chinese nation,has a long history and rich cultural connotations.Over the past few hundred years,a large number of active compounds with clear structure,significant activity and elucidated mechanism have been discovered.Their research constitutes the material basis for traditional Chinese medicine research.However,the natural components of traditional Chinese medicine have diverse skeletons and complex structures.In addition to small molecule monomer compounds,more and more recent studies have found that there are new forms of material basis for traditional Chinese medicines to exert their pharmacological effects,such as supramolecules formed by active monomer compounds,and bio-macromolecules with pharmacological activity.This article focuses on new forms of the material basis of traditional Chinese medicine,and through analysis of new technologies,mechanisms,and applications,it aims to provide new ideas for research on the material basis of efficacy in traditional Chinese medicine and its pharmacokinetic/pharmacodynamic correlation.

关 键 词：中药 物质基础新形式 超分子 生物大分子 药动/药效 

分 类 号：R284[医药卫生—中药学]