Photoelectric-driven conductive composite ionogel patch for effective wound healing  

作　　者：Xingkai Ju Jiao Kong Guohua Qi Shuping Hou Bo Wang Xingkang Diao Shaojun Dong Yongdong Jin 

机构地区：[1]State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China [3]Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging,School of Biomedical Engineering,Shenzhen University Medical School,Shenzhen University,Shenzhen 518060,China

出　　处：《eScience》2024年第2期92-100,共9页电化学与能源科学（英文）

基　　金：supported by the National Natural Science Foundation of China(grant No.22004117 and 21675146);Chinese Academy of Sciences for Special Research Assistant Grant.

摘　　要：Developing the high biosafety,effective and wearable devices for fast wound healing is highly desired but remains a challenge.Here,we propose a“win–win co-operation”strategy to potentiate effective skin wound healing at the wound site by constructing robust and ecofriendly composite patch under opto-electric stimulation.The wearable patch is composed of ionic gel doped with Ti3C2Tx(MXene),which possesses good photothermal response to kill the bacteria via effective inhibition of the expression of inflammatory factors,preventing wound infection.Importantly,the composite ionogel patch is capable of providing green and on-demand electrical stimulation for wound site,guiding cell migration and proliferation by improved bioenergy and expression up-regulation of growth factor.In mice wound models,the treatment group healed~31%more rapidly.Mechanistically,the wearable devices could enable visual and real-time supervising treatment effect due to their good transmittance.The proposed strategy would be promising for future clinical treatment of wound healing.

关 键 词：Wound healing Wearable composite ionogel patch ANTIBACTERIA Electrical stimulation Cell migration and proliferation 

分 类 号：R318[医药卫生—生物医学工程]