用于治疗牙周炎的抗菌药局部缓释递送系统的研究进展  

Research Progress on the Local Sustained-release Delivery Systems of Antibacterial Drugs for Periodontitis Treatment

作　　者：闫秋霖 吴恒乾 高岩 王正平 韩军 YAN Qiulin;WU Hengqian;GAO Yan;WANG Zhengping;HAN Jun(Institute of Biopharmaceutical Research,Liaocheng University,Liaocheng 252059;School of Chemistry and Chemical Engineering,Jinan University,Jinan 250022;Liaocheng High-Tech Biotechnology Co.,Ltd.,Liaocheng 252059)

机构地区：[1]聊城大学生物制药研究院,山东聊城252059 [2]济南大学化学化工学院,山东济南250022 [3]聊城高新生物技术有限公司,山东聊城252059

出　　处：《中国医药工业杂志》2024年第9期1186-1192,共7页Chinese Journal of Pharmaceuticals

基　　金：“重大新药创制”科技重大专项(2017ZX09201003-013);山东省泰山学者研究基金资助项目(319190201);山东省抗体药物协同创新中心开放项目(CIC-AD1828)。

摘　　要：牙周炎是由牙菌斑生物膜引起的牙周组织慢性感染,会导致牙齿松动、牙龈萎缩,主要致病菌包括牙龈卟啉单胞菌等。基于牙周袋内丰富的血管,局部递送抗菌药可使药物直接作用于病变部位,提高生物利用度。文章重点介绍了已上市的用于牙周炎治疗的可生物降解局部递药系统,总结了相关药物的处方及制备过程,以期为牙周炎治疗新剂型的开发提供参考。Periodontitis is a chronic infection of the periodontal tissue caused by the biofilm of dental plaque,which can lead to tooth loosening,gum atrophy.Its main pathogenic bacteria include Porphyromonas gingivalis.Based on the abundant blood vessels in the periodontal pocket,local delivery of antibacterial drugs can make drugs act directly on the lesion site and improve the bioavailability.This paper focuses on introducing biodegradable local drug delivery systems that have been marketed for the treatment of periodontitis,and summarizes the relevant drug prescriptions and preparation processes,hoping to provide a reference for the development of new dosage forms for the treatment of periodontitis.

关 键 词：牙周炎 局部药物递送 缓释 抗菌药 研究进展 

分 类 号：R944.9[医药卫生—药剂学] R781.42[医药卫生—药学] R978.1