纳米喷雾干燥技术的应用研究进展  

Application Progress of Nano Spray Drying Technology

作　　者：陈锐 许小红[1] CHEN Rui;XU Xiaohong(Chengdu Medical College,Chengdu 610500)

机构地区：[1]成都医学院,四川成都610500

出　　处：《中国医药工业杂志》2024年第9期1193-1200,共8页Chinese Journal of Pharmaceuticals

基　　金：四川省医学科研课题计划项目(S19021);成都医学院校基金项目(21Z098)。

摘　　要：纳米喷雾干燥是一种温和、有效的颗粒制备技术,创新性地采用了压电喷雾机制、层流加热方式和静电粒子收集系统,具有可调节微粒尺寸、改善溶解度、实现表面修饰等诸多优点,可高产量(90%)地获得纳米级颗粒。纳米喷雾干燥仪能处理的最小样品量可达毫克级。该文从纳米喷雾干燥技术的发展历程和技术特色出发,综述了纳米喷雾干燥机的结构和工作机制,汇总了影响纳米喷雾所得颗粒的处方和工艺参数,对其选择与优化提出建议。Nano spray drying is a mild and effective particle preparation technology.It innovatively adopts piezoelectric atomizing mechanism,laminar heating mode and electrostatic particle collection system,and has many advantages such as adjusting particle size,improving solubility,realizing surface modification.Nanoscale particles can be obtained with high output(90%)by this technology.The minimum sample volume processed by the nano spray dryer can reach milligram level.Starting from the development history and technical characteristics of nano spray drying technology,this paper introduces the structure and working mechanism of nano spray dryer,summarizes the formulation and process parameters affecting the properties of the obtained particles by nano spraying,and puts forward suggestions on their selection and optimization.

关 键 词：纳米喷雾干燥技术 纳米颗粒 制备 压电喷雾机制 应用 研究进展 

分 类 号：R943[医药卫生—药剂学] TQ460.5[医药卫生—药学]