以TOTM增塑的PVC输液器的药物相容性研究  

Drug Compatibility of PVC Infusion Sets Plasticized with TOTM

作　　者：王金鹏 孙国祥[1] WANG Jinpeng;SUN Guoxiang(College of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016)

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国医药工业杂志》2024年第9期1263-1270,共8页Chinese Journal of Pharmaceuticals

摘　　要：建立了HPLC-MS/MS法测定聚氯乙烯(PVC)输液器中偏苯三酸三辛酯(TOTM)的迁移量,用以考察PVC输液器与硝酸甘油、盐酸胺碘酮、甲磺酸酚妥拉明、甲硝唑、肌苷5种注射液的相容性。结果显示,在临床使用条件下,3批PVC输液器中TOTM的迁移量远低于成人可耐受限量,PVC输液器对硝酸甘油、盐酸胺碘酮具有比较明显的吸附作用,对甲磺酸酚妥拉明、甲硝唑、肌苷无明显吸附作用。该方法灵敏度高、操作简便、准确性好,适用于PVC输液器与药物的相容性研究。A HPLC-MS/MS method was established for the determination of the migration amount of trioctyl phthalate(TOTM)in PVC infusion sets,and the HPLC method was adopted to investigate the compatibility of PVC infusion sets with five types of injections,namely nitroglycerin,amiodarone hydrochloride,phentolamine mesylate,metronidazole,and inosine.The results showed that under the conditions used in clinic,the total migration amount of TOTM from three batches of PVC infusion sets was far below the permitted daily exposure(PDE)for adults.And the PVC infusion sets exhibited significant adsorption effects on nitroglycerin and amiodarone hydrochloride,whereas their adsorption effects on phentolamine mesilate,metronidazole and inosine were not observed.This method has high sensitivity,simple operation,and good accuracy,which is suitable for studying the compatibility of PVC infusion sets and drugs.

关 键 词：输液器 聚氯乙烯 偏苯三酸三辛酯 药物相容性 硝酸甘油 盐酸胺碘酮 甲磺酸酚妥拉明 甲硝唑 肌苷 

分 类 号：R917[医药卫生—药物分析学] TQ460.69[医药卫生—药学]