Engineered microorganisms:A new direction in kidney stone prevention and treatment  

作　　者：Wenlong Wan Weisong Wu Yirixiatijiang Amier Xianmiao Li Junyi Yang Yisheng Huang Yang Xun Xiao Yu 

机构地区：[1]Department of Urology,Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei Province,China

出　　处：《Synthetic and Systems Biotechnology》2024年第2期294-303,共10页合成和系统生物技术（英文）

摘　　要：Numerous studies have shown that intestinal and urinary tract flora are closely related to the formation of kidney stones.The removal of probiotics represented by lactic acid bacteria and the colonization of pathogenic bacteria can directly or indirectly promote the occurrence of kidney stones.However,currently existing natural probiotics have limitations.Synthetic biology is an emerging discipline in which cells or living organisms are genetically designed and modified to have biological functions that meet human needs,or even create new biological systems,and has now become a research hotspot in various fields.Using synthetic biology approaches of microbial engineering and biological redesign to enable probiotic bacteria to acquire new phenotypes or heterologous protein expression capabilities is an important part of synthetic biology research.Synthetic biology modification of microorganisms in the gut and urinary tract can effectively inhibit the development of kidney stones by a range of means,including direct degradation of metabolites that promote stone production or indirect regulation of flora homeostasis.This article reviews the research status of engineered microorganisms in the prevention and treatment of kidney stones,to provide a new and effective idea for the prevention and treatment of kidney stones.

关 键 词：Renal calculi Engineered microorganisms Synthetic biology Colony homeostasis Oxalate metabolism 

分 类 号：R318[医药卫生—生物医学工程] R692.4[医药卫生—基础医学]