Single carbon metabolism–A new paradigm for microbial bioprocesses?  

作　　者：Michael Baumschabl Özge Ata Diethard Mattanovich 

机构地区：[1]Austrian Centre of Industrial Biotechnology(ACIB),Vienna,1190,Austria [2]University of Natural Resources and Life Sciences,Department of Biotechnology,Institute of Microbiology and Microbial Biotechnology,Vienna,Austria

出　　处：《Synthetic and Systems Biotechnology》2024年第2期322-329,共8页合成和系统生物技术（英文）

基　　金：The work of M.B.,O.A.and D.M.was supported by the Federal Ministry for Digital and Economic Affairs,the Federal Ministry for Climate Action,Environment,Energy,Mobility,Innovation and Technology,the Styrian Business Promotion Agency SFG,the Standortagentur Tirol,the Government of Lower Austria and ZIT-Technology Agency of the City of Vienna through the COMET Funding Program managed by FFG.O.A.,and D.M.are members of the VIVALDI project which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101000441.The authors thank the Austrian Science Fund for support to M.B.and D.M.(FWF W1224,Doctoral Program on Biomolecular Technology of Proteins(BioToP)),to O.A.(Grant-DOI 10.55776/M2891);to D.M.and O.A.(Grant-DOI 10.55776/I6795).

摘　　要：Increasing atmospheric carbon dioxide levels,a reduction of arable land area and the dependence of first and second generation biotechnology feedstocks on agricultural products,call for alternative,sustainable feedstock sources for industrial applications.The direct use of CO_(2)or conversion of CO_(2)into other single carbon(C1)sources have great potential as they might help to reduce carbon emissions and do not compete with agricultural land use.Here we discuss the microbial use of C1 carbon sources,their potential applications in biotechnology,and challenges towards sustainable C1-based industrial biotechnology processes.We focus on methanol,formic acid,methane,syngas,and CO_(2)as feedstocks for bioprocesses,their assimilation pathways,current and emerging applications,and limitations of their application.This mini-review is intended as a first introduction for researchers who are new to the field of C1 biotechnology.

关 键 词：Sustainability BioeconomyCarbon dioxide METHANOL FORMATE Methane 

分 类 号：Q81[生物学—生物工程]