Bayesian estimation of the time-varying reproduction number for pulmonary tuberculosis in Iran:A registry-based study from 2018 to 2022 using new smear-positive cases  

作　　者：Maryam Rastegar Eisa Nazar Mahshid Nasehi Saeed Sharafi Vahid Fakoor Mohammad Taghi Shakeri 

机构地区：[1]Department of Biostatistics,School of Health,Mashhad University of Medical Sciences,Mashhad,Iran [2]Orthopedic Research Center,Mazandaran University of Medical Sciences,Sari,Iran [3]Centre for Communicable Diseases Control,Ministry of Health and Medical Education,Tehran,Iran [4]Department of Statistics,Faculty of Mathematical Sciences,Ferdowsi University of Mashhad,Mashhad,Iran [5]Social Determinants of Health Research Center,Mashhad University of Medical Sciences,Mashhad,Iran [6]Department of Epidemiology,School of Public Health,Iran University of Medical Sciences,Tehran

出　　处：《Infectious Disease Modelling》2024年第3期963-974,共12页传染病建模（英文）

基　　金：This study was financially supported by the Vice-chancellor for Research and Technology,Mashhad University of Medical Sciences,Iran(project No.4001759).

摘　　要：Introduction Tuberculosis(TB)is one of the most prevalent infectious diseases in the world,causing major public health problems in developing countries.The rate of TB incidence in Iran was estimated to be 13 per 100,000 in 2021.This study aimed to estimate the reproduction number and serial interval for pulmonary tuberculosis in Iran.Material and methods The present national historical cohort study was conducted from March 2018 to March 2022 based on data from the National Tuberculosis and Leprosy Registration Center of Iran's Ministry of Health and Medical Education(MOHME).The study included 30,762 tuberculosis cases and 16,165 new smear-positive pulmonary tuberculosis patients in Iran.We estimated the reproduction number of pulmonary tuberculosis in a Bayesian framework,which can incorporate uncertainty in estimating it.Statistical analyses were accomplished in R software.Results The mean age at diagnosis of patients was 52.3±21.2 years,and most patients were in the 35–63 age group(37.1%).Among the data,9121(56.4%)cases were males,and 7044(43.6%)were females.Among patients,7459(46.1%)had a delayed diagnosis between 1 and 3 months.Additionally,3039(18.8%)cases were non-Iranians,and 2978(98%)were Afghans.The time-varying reproduction number for pulmonary tuberculosis disease was calculated at an average of 1.06±0.05(95%Crl 0.96–1.15).Conclusions In this study,the incidence and the time-varying reproduction number of pulmonary tuberculosis showed the same pattern.The mean of the time-varying reproduction number indicated that each infected person is causing at least one new infection over time,and the chain of transmission is not being disrupted.

关 键 词：Reproduction number Bayesian modeling TUBERCULOSIS Iran 

分 类 号：R521[医药卫生—内科学]