意外抗体阳性孕妇备血策略回顾分析  

Retrospective analysis of blood preparation strategies for pregnant women with unexpected antibody positive

作　　者：唐会珍 屈明利 褚晓月 TANG Huizhen;QU Mingli;CHU Xiaoyue(Blood Transfusion Department,Northwest Women's and Children's Hospital,Xi'an 710061;Shaanxi Blood Center,Xi'an 710061,China)

机构地区：[1]西北妇女儿童医院输血科,陕西西安710061 [2]陕西省血液中心,陕西西安710061

出　　处：《临床医学研究与实践》2024年第29期14-17,共4页Clinical Research and Practice

基　　金：陕西省卫生健康科研基金项目(No.2022D050)。

摘　　要：目的分析意外抗体阳性孕妇的备血情况,探究备血策略,以提高产科用血的安全性和时效性。方法选择2021年12月至2022年12月在西北妇女儿童医院检测意外抗体的5682名孕晚期孕妇为研究对象,分析不同胎次孕妇的抗体阳性率、盲配血与特配血相合率、意外抗体分布以及临床用血量。结果5682名孕妇的标本中检出意外抗体阳性123例;意外抗体阳性孕妇中,一、二、三胎孕妇的阳性率分别为1.55%、3.03%、8.06%,不同胎次抗体筛查阳性率比较,差异具有统计学意义(P<0.05)。盲配血和特配血相合率比较,差异具有统计学意义(P<0.05)。34例意外抗体中共检出8种抗体,共39例,其中抗-E占比最高(53.85%)。123例意外抗体阳性孕妇在住院期间用血者9例,其中盲配血5例,特配血6例,共备血34 U,用血25 U。结论对于意外抗体阳性的孕妇,应结合实际情况灵活采用盲配和特配相结合的策略,提前准备血液,保证产妇的用血安全。Objective To analyze the blood preparation of pregnant women with unexpected antibody positive and explore the blood preparation strategy,so as to improve the safety and timeliness of obstetric blood use.Methods From December 2021 to December 2022,5682 pregnant women in the third trimester of pregnancy who were tested for unexpected antibody in Northwest Women's and Children's Hospital were selected as the research objects.The antibody positive rate,blind matching and special matching rate,unexpected antibody distribution and clinical blood use of pregnant women with different parity were analyzed.Results One hundred and twenty-three cases of unexpected antibody positive were detected in 5682 pregnant women;among the pregnant women with unexpected antibody positive,the positive rates of the first,second and third births were 1.55%,3.03%and 8.06%,respectively,there was a statistically significant difference in the positive rate of antibody screening among different parity(P<0.05).There was a statistically significant difference in the coincidence rate between blind blood matching and special blood matching(P<0.05).A total of 8 antibodies were detected in 34 cases of unexpected antibody,with a total of 39 cases,of which anti-E accounted for the highest proportion(53.85%).Among the 123 pregnant women with unexpected antibody positive,9 cases used blood during hospitalization,including 5 cases of blind blood matching and 6 cases of special blood matching,a total of 34 U of blood was prepared and 25 U of blood was used.Conclusion For pregnant women with unexpected antibody positive,the strategy of combining blind matching and special matching should be flexibly adopted in combination with the actual situation,and blood should be prepared in advance to ensure the safety of maternal blood use.

关 键 词：意外抗体 抗体鉴定 备血 孕妇 

分 类 号：R446.6[医药卫生—诊断学]