三氧自血疗法配合抗结核治疗对活动性肺结核患者免疫功能指标的影响  

Effects of trioxy autoblood therapy combined with anti-tuberculosis treatment on immune function indexes of patients with active pulmonary tuberculosis

作　　者：张婧 魏景亮 ZHANG Jing;WEI Jingliang(Prevention and Health Section Department,the First Affiliated Hospital of Air Force Military Medical University,Xi'an 710032;Quality Control Department,the Second Affiliated Hospital of Air Force Military Medical University,Xi'an 710038,China)

机构地区：[1]空军军医大学第一附属医院预防保健科,陕西西安710032 [2]空军军医大学第二附属医院质管科,陕西西安710038

出　　处：《临床医学研究与实践》2024年第29期39-42,共4页Clinical Research and Practice

摘　　要：目的分析三氧自血疗法配合抗结核治疗对活动性肺结核(PTB)患者免疫功能指标的影响。方法选择2020年1月至12月收治的100例活动性PTB患者作为研究对象,以红蓝球随机法将其分为对照组和三氧自血组,各50例。对照组给予常规抗结核治疗,三氧自血组在对照组基础上给予三氧自血疗法。比较两组的治疗效果。结果三氧自血组的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、CD56^(+)、CD19^(+)及CD45^(+)比较,差异无统计学意义(P>0.05);治疗后,三氧自血组的CD4^(+)、CD4^(+)/CD8^(+)、CD56^(+)及CD45^(+)显著高于对照组,CD8^(+)、CD19^(+)显著低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)及白细胞介素-34(IL-34)水平比较,差异无统计学意义(P>0.05);治疗后,三氧自血组的TNF-α、CRP及IL-34水平显著低于对照组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论三氧自血疗法配合常规抗结核治疗用于活动性PTB患者中可取得理想治疗效果。Objective To analyze the effects of trioxy autoblood therapy combined with anti-tuberculosis treatment on immune function indexes in patients with active pulmonary tuberculosis(PTB).Methods A total of 100 patients with active PTB admitted from January to December 2020 were selected as the research objects.The patients were divided into control group and trioxy autoblood group by red blue ball random method,with 50 cases in each group.The control group was given conventional anti-tuberculosis treatment,and the trioxy autoblood group was given trioxy autoblood therapy on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of the trioxy autoblood group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in CD4^(+),CD8^(+),CD4^(+)/CD8^(+),CD56^(+),CD19^(+)and CD45^(+)between the two groups(P>0.05);after treatment,the CD4^(+),CD4^(+)/CD8^(+),CD56^(+)and CD45^(+)in the trioxy autoblood group were significantly higher than those in the control group,and the CD8^(+)and CD19^(+)were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-34(IL-34)between the two groups(P>0.05);after treatment,the levels of TNF-α,CRP and IL-34 in the trioxy autoblood group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Trioxy autoblood therapy combined with conventional anti-tuberculosis treatment can achieve ideal therapeutic effect in patients with active PTB.

关 键 词：活动性肺结核 抗结核治疗 三氧自血疗法 

分 类 号：R521[医药卫生—内科学]