原发性高血压患者Lp(a)、Lp-PLA2水平与血压变异性的相关性  

The Correlation Between Lp PLA2,Lp(a)Levels and Blood Pressure Variability in Patients with Essential Hypertension

作　　者：苏日娜[1,2] 灵小 赵兴胜 Surina;LING Xiao;ZHAO Xingsheng(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040 China;Department of Cardiovascular Medicine,Inner Mongolia Autonomous Region People's Hospital,Hohhot 010017 China)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014040 [2]内蒙古自治区人民医院心血管内科,呼和浩特010017

出　　处：《内蒙古医学杂志》2024年第9期1051-1055,1060,共6页Inner Mongolia Medical Journal

摘　　要：目的通过研究原发性高血压(EH)患者的血清Lp(a)、Lp-PLA2水平与血压变异性(BPV)的特征,进一步探讨EH患者血清中Lp(a)和Lp-PLA2水平与BPV之间的关系。方法选取2022年9月至2023年9月于内蒙古自治区人民医院门诊及住院诊疗的EH患者240例。将患者分为A组:Lp(a)、Lp-PLA2均正常,115例;B组:仅Lp(a)升高,48例;C组:仅Lp-PLA2升高,42例;D组:Lp(a)、Lp-PLA2均升高,35例。探索Lp(a)和Lp-PLA2水平与血压变异性之间的相关性。结果B组各时段变异系数(CV)均高于A组(P<0.05);C组24 h SBPCV、24 h DBP CV、nSBP CV、dDBP CV、dSBP CV高于A组(P<0.05);D组各时段CV均高于A组(P<0.05)。Lp(a)、Lp-PLA2与BPV呈正相关(rs>0,P<0.05)。B组、C组以及D组的Lp(a)、Lp-PLA2和24 h SBP CV、24 h DBP CV间均呈显著正相关关系(rs>0,P<0.05)。结论EH患者血清Lp(a)、Lp-PLA2水平与BPV呈正相关,且血清Lp(a)、Lp-PLA2均升高的患者BPV也升高。Objective Through an analysis of serum Lp(a)and Lp-PLA2 levels as well as blood pressure variability(BPV)in individuals diagnosed with essential hypertension,a deeper investigation was conducted into the connection between serum Lp(a)and Lp-PLA2 levels and BPV among those with EH.Methods Between September 2022 and September 2023,a total of 240 patients diagnosed with essential hypertension were carefully selected from both the outpatient and inpatient departments of Inner Mongolia Autonomous Region People's Hospital.The patients were divided into group A:Lp(a)and LP-PLA2 normal group(115 cases);Group B:Lp(a)only increased group(48 cases);Group C:only Lp-PLA2 elevated group(42 cases);Group D:Lp(a)and LP-PLA2 both increased group(35 cases),to explore the correlation between Lp(a)and LP-PLA2 levels and blood pressure variability.Results The coefficient of variation(CV)in group B exhibited a significantly higher value compared to group A(P<0.05).Moreover,24 h SBP CV,24 h DBP CV,nSBP CV,dDBP CV,and dSBP CV in group C demonstrated notably elevated levels in contrast to group A(P<0.05).Additionally,the CV in group D surpassed that in group A(P<0.05).Lipoprotein(a)[Lp(a)]and lipoprotein-associated phospholipase A2(LP-PLA2)showed a positive correlation with blood pressure variability(BPV)(rs>0,P<0.05).There was a significant positive correlation between Lp(a),LP-PLA2,24 h SBP CV,and 24 h DBP CV in groups B,C,and D(rs>0,P<0.05).Conclusion There was a positive correlation between serum levels of Lp(a)and LP-PLA2 and BPV in patients with EH.The concentrations of Lp(a)and LP-PLA2 in the serum of EH patients exceeded those found in individuals without EH.

关 键 词：原发性高血压 Lp(a) LP-PLA2 血压变异性 

分 类 号：R544.1[医药卫生—心血管疾病]