以减重与代谢手术为主的综合治疗在肥胖低生育女性中的应用进展  

Application Progress of Comprehensive Treatment Mainly Based on Bariatric-metabolic Surgery for Obese and Low Fertility Women

作　　者：高科 王举 GAO Ke;WANG Ju(Inner Mongolia Medical University,Hohhot 010000,China;Department of Gastroenterology,Inner Mongolia Autonomous Region People′s Hospital,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学,呼和浩特010000 [2]内蒙古自治区人民医院胃肠外科,呼和浩特010000

出　　处：《医学综述》2024年第21期2664-2669,2676,共7页Medical Recapitulate

摘　　要：育龄期女性代谢异常型肥胖会对机体生殖内分泌稳态产生影响,肥胖诱发生育力低下的发病机制可能与性激素稳态的失衡、代谢性疾病及妊娠期特有疾病的发生有关。目前减重与代谢手术(BMS)是肥胖不孕妇女的试验性治疗手段,其改善代谢的机制可能涉及消化道结构重塑后的体质量降低、胃肠激素分泌的调节以及肠道菌群的改变等。BMS后,人体消化、吸收功能发生适应性变化,受孕准备阶段可依据机体代谢改善情况辅以小剂量、短疗程的药物及营养支持干预。未来,以BMS为主的综合治疗有望成为治疗肥胖低生育女性的新方法。Abnormal metabolic obesity in women of childbearing age can affect the reproductive endocrine homeostasis of the body.The pathogenesis of obesity induced low fertility may be related to the imbalance of sex hormone homeostasis,metabolic diseases,and pregnancy specific diseases.Bariatric-metabolic surgery(BMS)is currently an investigational treatment for obese infertile women,and its mechanism of improving metabolism may involve reduced body mass after gastrointestinal structural remodeling,regulation of gastrointestinal hormone secretion,and changes in gut microbiota.After BMS,the digestive and absorption functions of the human body undergo adaptive changes.In the preparation stage for conception,low-dose,short-term medication and nutritional support interventions can be supplemented according to the improvement of the body′s metabolism.In the future,comprehensive treatment based on BMS is expected to become a new method for obese and low fertility women.

关 键 词：肥胖 减重与代谢手术 生育力 

分 类 号：R723.14[医药卫生—儿科]