线粒体DNA激活的先天免疫在动脉粥样硬化中的研究进展  

Research progress of innate immunity activated by mitochondrial DNA in atherosclerosis

作　　者：郑峻萌 王婷婷 陈玉善[1] 沈祥丽 卢明凯 尚莎莎 宗永华 解金红[1] Zheng Jun-meng;Wang Ting-ting;Chen Yu-shan;Shen Xiang-li;Lu Ming-kai;Shang Sha-sha;Zong Yong-hua;Xie Jin-hong(Heart Center/National Regional(Traditional Chinese Medicine)Cardiovascular Diagnosis and Treatment Center,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,Henan 450000,China)

机构地区：[1]河南中医药大学第一附属医院心脏中心/国家区域(中医)心血管诊疗中心,河南郑州450000

出　　处：《中国现代医学杂志》2024年第19期44-50,共7页China Journal of Modern Medicine

基　　金：国家重点研发计划(No:2020YFC2004706);国家自然科学基金(No:82004311);河南省中医药科学研究专项课题(No:2019JDZX2044、2022JDZX026、2024ZY2026);河南省卫生健康委国家中医药传承创新专项课题(No:2023ZXZX1001)。

摘　　要：线粒体是细胞能量制造和生物合成的控制中心。近年来,越来越多的研究强调了线粒体作为免疫调节因子的作用。功能失调的线粒体可释放线粒体DNA(mtDNA)或其他线粒体成分到细胞质或细胞外,激活机体的免疫炎症。动脉粥样硬化(AS)是一种发生在大动脉或中动脉的多因素慢性炎症疾病,可引起多种心脑血管并发症,严重危害人类的生命健康。最新研究发现,AS血管中mtDNA释放增加并伴随免疫炎症的激活。该文对mtDNA在AS血管炎症中的作用机制进行全面总结,深入讨论AS中功能失调的线粒体释放的mtDNA通过哪些模式识别受体PRRs诱导血管的免疫炎症,以期为AS的防治提供新的策略和靶点。Mitochondria are the control centers of the cell's energy production and biosynthesis.Recently,more and more studies have emphasized the role of mitochondria as immune regulatory factors.Dysfunctional mitochondria release mitochondrial DNA(mtDNA)and other mitochondrial components into the cytoplasm or beyond the cell,where they then activate the immune inflammatory response.Atherosclerosis(AS)is a multi-factor chronic disease occurring in the great artery or middle artery,which can cause a variety of cardiovascular and cerebrovascular complications and seriously endanger human life and health.Recent studies have found that there is the release of mtDNA and its activation of immune inflammation in the blood vessel wall of AS.This review provides a comprehensive summary of the mechanism of action of mtDNA in vascular inflammation of AS,and further discusses which pattern recognition receptors(PRRs)can recognize mtDNA released by dysfunctional mitochondria to promote immune inflammation of blood vessels in AS.These provide new strategies and targets for the prevention and treatment of AS.

关 键 词：动脉粥样硬化 线粒体DNA 模式识别受体 炎症 

分 类 号：R543.5[医药卫生—心血管疾病]