复方丹参滴丸对慢性高原病患者的影响  

Effect of Compound Danshen Dropping Pills on Chronic Mountain Sickness Patients

作　　者：杨丽 鲁雪 YANG Li;LU Xue(The Fifth People's Hospital of Qinghai Province,Xining 810007,China;不详)

机构地区：[1]青海省第五人民医院,青海西宁810007 [2]青海省藏医院

出　　处：《中外医学研究》2024年第28期30-34,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨复方丹参滴丸对慢性高原病(CMS)患者的影响。方法:回顾性选取2022年2月—2023年2月青海省第五人民医院收治的86例CMS患者。根据治疗方案的不同将其分为研究组和对照组,各43例。两组均给予常规治疗,对照组采用甲磺酸酚妥拉明注射液治疗,研究组在对照组基础上给予复方丹参滴丸。比较两组治疗前后相关指标、左心室结构及左心室功能指标、肺功能指标、6 min步行距离及临床疗效。结果:治疗后,两组去甲肾上腺素(NE)、肾上腺素(E)、心钠素(ANP)、内皮素(ET)均降低,一氧化氮(NO)升高,研究组NE、E、ANP、ET均低于对照组,NO高于对照组,差异有统计学意义(P<0.05)。治疗后,两组左室舒张末内径(LVEDD)、左心室后壁厚度(PWT)、室间隔厚度(IVS)均降低,研究组LVEDD、IVS、PWT均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组心房收缩期二尖瓣口血流速度(A)降低,左室快速充盈期二尖瓣口血流速度(E)、E/A、左室射血分数(LVEF)、心排血量(CO)均升高,研究组A低于对照组,E、E/A、LVEF、CO均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组肺动脉压(PAP)降低,用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、FEV_(1)/FVC%、6分钟步行试验(6MWT)均升高,研究组PAP低于对照组,FVC、FEV_(1)、FEV_(1)/FVC%、6MWT均高于对照组,差异有统计学意义(P<0.05)。研究组总有效率高于对照组,差异有统计学意义(P<0.05)。结论:复方丹参滴丸对CMS患者心肺功能结构均有明显的改善作用,临床疗效较好。Objective:To investigate the effect of Compound Danshen Dropping Pills on patients with chronic mountain sickness(CMS).Method:A total of 86 patients with CMS admitted to the Fifth People's Hospital of Qinghai Province from February 2022 to February 2023 were retrospectively selected.According to different method of treatment,the patients were divided into study group and control group,43 cases in each group.Both groups were given conventional treatment,the control group was treated with Phentolamine Mesylate Injection,and the study group was given Compound Danshen Dropping Pills on the basis of the control group.The relevant indexes,left ventricular structure,left ventricular function,lung function,6 min walking distance before and after treatment and clinical efficacy of the two groups were compared.Result:After treatment,norepinephrine(NE),epinephrine(E),atrial natriuretic peptide(ANP)and endothelin(ET)were decreased in both groups,while nitric oxide(NO)was increased,NE,E,ANP and ET in the study group were lower than those in the control group,and NO was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,left ventricular end-diastolic diameter(LVEDD),left ventricular posterior wall thickness(PWT)and ventricular septal thickness(IVS)were decreased in both groups,and LVEDD,IVS and PWT in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,atrial systolic mitral valve velocity(A)decreased,while mitral valve velocity during left ventricular rapid filling phase(E),E/A,left ventricular ejection fraction(LVEF)and cardiac output(CO)increased in both groups,and A in study group was lower than that in control group,and E,E/A,LVEF and CO were higher than those in control group,the differences were statistically significant(P<0.05).After treatment,pulmonary artery pressure(PAP)decreased,forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1)),FEV_(1)/FVC%,6 minutes

关 键 词：超声心动图 复方丹参滴丸 慢性高原病 心肺功能 

分 类 号：R259[医药卫生—中西医结合]