化瘀通络灸联合认知功能训练对卒中后认知功能障碍患者认知功能及血清VEGF水平的影响  

Effect of Huayu Tongluo Moxibustion Combined with Cognitive Function Training on Cognitive Function and Serum VEGF Level in Patients with PSCI

作　　者：姚婷婷[1] 于若凡 朱永法 苏强 杨骏[2] 张庆萍[3] YAO Tingting;YU Ruofan;ZHU Yongfa;SU Qiang;YANG Jun;ZHANG Qingping(The Second Affiliated Hospital of Bengbu Medical University,Bengbu 233002,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China;Anhui University of Chinese Medicine,Hefei 230012,China)

机构地区：[1]蚌埠医学院第二附属医院,安徽蚌埠233002 [2]安徽中医药大学第一附属医院,安徽合肥230031 [3]安徽中医药大学,安徽合肥230012

出　　处：《针灸临床杂志》2024年第10期17-21,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：国家自然科学基金,编号:8157151194;蚌埠医学院自然科学重点项目,编号:2021byzd209。

摘　　要：目的:比较化瘀通络灸联合认知功能训练与单纯认知功能训练治疗卒中后认知功能障碍(PSCI)的临床疗效及对血管内皮生长因子(VEGF)水平的影响。方法:采集2021年6月—2023年6月蚌埠医学院第二附属医院门诊或住院患者,采用随机数字表法将两组患者分为观察组20例、对照组20例。观察组予以化瘀通络灸治疗联合认知功能训练,对照组仅予以认知功能训练,3次/周,4周为1个疗程,两组均连续治疗12周。比较两组MMSE、MoCA、ADL及血清VEGF水平,并评定临床疗效。结果:治疗12周后,两组患者MMSE、MoCA及ADL评分均较治疗前明显提高,差异具有统计学意义(P<0.01),并且观察组分值均高于对照组,差异具有统计学意义(P<0.05);治疗12周后,两组血清VEGF水平较治疗前提高,差异具有统计学意义(P<0.05),并且观察组水平优于对照组,差异具有统计学意义(P<0.01)。观察组总有效率为90.00%(18/20),高于对照组总有效率75.00%(15/20),差异具有统计学意义(P<0.05)。结论:化瘀通络灸结合认知功能训练治疗PSCI可有效提高患者认知功能及日常生活能力,且疗效优于单纯认知功能训练,其发挥作用机制可能与调节血清VEGF水平有关。Objective:To compare the clinical efficacy and effects on vascular endothelial growth factor level(VEGF)between Huayu Tongluo moxibustion combined with cognitive function training and cognitive function training alone in treatment of post-stroke cognitive impairment(PSCI).Methods:All cases were collected from June 2021 to June 2023 in the Second Affiliated Hospital of Bengbu Medical University.The patients were divided into the observation group and the control group,with 20 patients in each group.The observation group was treated with Huayu Tongluo moxibustion and cognitive function training,whereas the control group was only treated with cognitive function training.The intervention was three times a week for 12 weeks.The scores of MMSE,MoCA and ADL,the serum level of VEGF,as well as the clinical efficacy was compared between the two groups.Results:After 12 weeks of the treatment,the scores of MMSE,MoCA and ADL were significantly increased compared with those before the treatment in the two groups(P<0.01),and the scores were higher in the observation group than those in the control group(P<0.05).The serum level of VEGF were increased after 12 weeks of the treatment than that before the treatment in the two groups(P<0.05),and the level of VEGF was higher in the observation group than that in the control group(P<0.01).The total effective rate was 90.00%(18/20)in the observation group,which was higher than 75.00%(15/20)in the control group(P<0.05).Conclusion:The combination of Huayu Tongluo moxibustion and cognitive function training can effectively improve patients'cognitive function and daily living ability,and the curative effect is better than that of simple cognitive function training.The function mechanism may be related to the regulation of serum VEGF level.

关 键 词：卒中 认知功能障碍 化瘀通络灸 认知功能 血管内皮生长因子 

分 类 号：R246.6[医药卫生—针灸推拿学]