Differences in Toxicokinetics and Maternal Transfer between Lipophilic and Proteinophilic Halogenated Organic Pollutants in Laying Hens  

作　　者：Xiao-Jun Luo Qun-Jie Feng Chu-Hong Zhu Xi Chen Peng-Peng Chen Yan-Hong Zeng Bi-Xian Mai 

机构地区：[1]State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Resources Utilization and Protection and Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou 510640,P.R.China [2]State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Resources Utilization and Protection,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou 510640,P.R.China [3]University of Chinese Academy of Sciences,Beijing 100049,P.R.China

出　　处：《Environment & Health》2024年第10期712-720,共9页环境与健康（英文）

基　　金：funded by the National Nature Science Foundation of China(Nos.U23A2056,42277267,42321003);Guangdong Major Project of Basic and Applied Basic Research(2023B0303000007);Guangdong Foundation for the Program of Science and Technology Research(Nos.2023B1212060049);This is a contribution No.IS-3527 from GIGCAS.

摘　　要：In this study,we conducted exposure experiments on egg-laying hens to explore the toxicokinetics and maternal transfer characteristics of lipophilic and proteinophilic halogenated organic pollutants(HOPs).The lipophilic HOPs included polychlorinated biphenyls(PCBs),polybrominated diphenyl ethers(PBDEs),and dechlorane plus(DPs),while the proteinophilic HOPs included perfluorocarboxylic acids(PFCAs).The results revealed that most of lipophilic HOPs exhibit lower depuration rate(kd)than PFCAs.The kd of lipophilic HOPs correlated with the octanol−water partition coefficient(log KOW)values in a V-shaped curve,whereas that of PFCAs correlated with the protein−water partition coefficient(log KPW)values in an inverted V-shaped curve.The depuration rate,rather than the uptake rate,was a leading factor in determining the bioaccumulation potential of HOPs in hens.Although the dominant factors determining the tissue distribution of the two types of compounds were explicit(fats vs phospholipids),chemical-specific tissue distribution was still observed.The egg-maternal concentration ratio was dependent on the exposure status,concentration,and maternal tissue choice.Using a single maternal tissue may not be an appropriate method for assessing chemical maternal transfer potential.PFCAs have a greater maternal transfer potential(>80%of the total body burden)than lipophilic HOPs(approximately 30%for BDE209 and DPs,and less than 10%for the others).Their lipophilic and partly proteinophilic nature makes the toxicokinetics and maternal transfer characteristics of BDE209 and DPs different from those of other lipophilic HOPs.These findings are crucial for enhancing our understanding of the behavior and fate of HOPs in egg-laying hens.

关 键 词：halogenated organic pollutants laying hens TOXICOKINETIC maternal transfer 

分 类 号：X592[环境科学与工程—环境工程]