Associations of Gestational Exposure to Air Pollution and Polycyclic Aromatic Hydrocarbons with Placental Inflammation  

作　　者：Emily A.Craig Yan Lin Yihui Ge Xiangtian Wang Susan K.Murphy Donald K.Harrington Richard K.Miller Sally W.Thurston Philip K.Hopke Emily S.Barrett Thomas G.O’Connor David Q.Rich Junfeng Zhang 

机构地区：[1]Nicholas School of the Environment&Duke Global Health Institute,Duke University,Durham,North Carolina 27708,United States [2]Department of Psychiatry,University of Rochester School of Medicine and Dentistry,Rochester,New York 14642,United States [3]Department of Obstetrics and Gynecology,University of Rochester School of Medicine and Dentistry,Rochester,New York 14642,United States [4]Department of Environmental Medicine and Department of Pediatrics,University of Rochester School of Medicine and Dentistry,Rochester,New York 14642,United States [5]Department of Psychology,University of Rochester,Rochester,New York 14642,United States [6]Department of Biostatistics and Computational Biology and Department of Environmental Medicine,University of Rochester School of Medicine and Dentistry,Rochester,New York 14642,United States [7]Department of Public Health Sciences,University of Rochester School of Medicine and Dentistry,Rochester,New York 14642,United States [8]Department of Biostatistics and Epidemiology,Rutgers School of Public Health,Piscataway,New Jersey 08854,United States [9]Department of Psychiatry and Department of Neuroscience,University of Rochester School of Medicine and Dentistry,Rochester,New York 14642,United States [10]Department of Public Health Sciences,Department of Medicine,and Department of Environmental Medicine,University of Rochester School of Medicine and Dentistry,Rochester,New York 14642,United States

出　　处：《Environment & Health》2024年第9期672-680,共9页环境与健康（英文）

基　　金：funded by the National Institutes of Health(R01ES027495,UG3 OD023349,HD083369);The Wynne Center for Family Research;The National Center for Advancing Translational Sciences of the National Institutes of Health(UL1 TR002001);the University of Rochester CTSA。

摘　　要：Restricted fetal growth(RFG)is a leading contributor to perinatal mortality and has been associated with gestational exposure to air pollution,such as fine particulate matter(PM_(2.5)),nitrogen dioxide(NO2),and polycyclic aromatic hydrocarbons(PAHs).This study examines the association between trimester-specific and weekly means of air pollution throughout gestation and placental inflammatory markers at delivery.In a prospective cohort study of 263 pregnant women in Rochester,NY,we measured interleukin-6(IL-6)and tumor necrosis factor-alpha(TNF-α)in placental tissue and estimated gestational exposure to PM_(2.5)and NO_(2)using a high-resolution spatial-temporal model.Exposure to PAHs was estimated using urinary 1-hydroxypyrene(1-OHP)concentrations collected once per trimester.Using distributed lag models with a penalized spline function,each interquartile range(2.6μg/m^(3))increase in PM_(2.5)concentration during gestational weeks 6−11 was associated with decreased placental IL-6 levels(−22.2%,95%CI:−39.0%,−0.64%).Using multiple linear regression models,each interquartile range increase of 1-OHP was associated with an increase in TNF-αin the first trimester(58.5%,95%CI:20.7%,74.2%),third trimester(22.9%,95%CI:0.04%,49.5%),and entire pregnancy(29.6%,95%CI:3.9%,60.6%).Our results suggest gestational exposure to air pollution may alter the inflammatory environment of the placenta at delivery.

关 键 词：pregnancy air pollution PAHs PLACENTA tumor necrosis factor INTERLEUKIN 

分 类 号：X51[环境科学与工程—环境工程] R71[医药卫生—妇产科学]