Canine on the Couch:The New Canary in the Coal Mine for Environmental Health Research  

作　　者：Catherine F.Wise Matthew Breen Heather M.Stapleton 

机构地区：[1]Nicholas School of the Environment,Duke University,Durham,North Carolina 27708,United States [2]Duke Cancer Institute,Durham,North Carolina 27710,United States [3]Department of Molecular Biomedical Sciences,College of Veterinary Medicine,North Carolina State University,1060 William Moore Drive,Raleigh,North Carolina 27607,United States [4]Comparative Medicine Institute,North Carolina State University,Raleigh,North Carolina 27607,United States [5]Center for Human Health and the Environment,North Carolina State University,Raleigh,North Carolina 27607,United States

出　　处：《Environment & Health》2024年第8期517-529,共13页环境与健康（英文）

摘　　要：Human health is intimately connected and tied to the health of our environment and ecosystem,with only a very small fraction of the risk for chronic diseases explained by genetics alone.Companion animals are prone to disease types that are shared with people,including cancers and endocrine disorders,reinforcing the thought that environmental factors contribute to the risks for chronic diseases.These factors include air and water pollution and the built environment.As such,there is increasing interest in pursuing research with companion animals,and specifically dogs,as sentinel species to inform comparative health assessments and identify risk factors for disease.Of the canine diseases for which environmental exposure research has been published,cancers have received the most attention.This review summarizes two main aspects of this comparative approach:(1)cancers that occur in dogs and which are similar to humans and(2)research investigating environmental exposures and health outcomes in dogs.The goal of this review is to highlight the diverse conditions in which pet dogs may provide unique perspectives and advantages to examine relationships between environmental exposures and health outcomes,with an emphasis on chemical pollution and cancer.Furthermore,this review seeks to raise awareness and stimulate discussion around the best practices for the use of companion animals as environmental health sentinels.

关 键 词：sentinels DOGS environmental health comparative oncology cancer alternative models environmental exposure 

分 类 号：R12[医药卫生—环境卫生学]