Percutaneous Penetration and Dermal Exposure Risk Assessment of UV Absorbents in Sunscreens and Isolation Cosmetics  

作　　者：Lu Bai Juan Li Binbin Guo Ruitong Cai Chunyan Zhao Yanli Guo Yawei Wang Guibin Jiang 

机构地区：[1]State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China [2]School of Environment,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310000,China [3]College of Resources and Environment,University of Chinese Academy of Sciences,Beijing 100049,China [4]School of Pharmacy,Lanzhou University,Lanzhou 730000,China [5]China Innovation Center,Shimadzu(China)Co.,Beijing 100020,China

出　　处：《Environment & Health》2024年第8期541-552,共12页环境与健康（英文）

基　　金：We gratefully acknowledge the financial support from the National Natural Science Foundation of China(22136006,22021003,and 22106169);Strategic Priority Research Program of the Chinese Academy of Sciences,Grant XDB0750000.

摘　　要：Ultraviolet absorbents(UVs)make up a group of industrial chemicals that is used in various consumer products and industrial applications.Due to their extensive production and usage,UVs have been detected in multiple environmental matrixes.Recently,UVs have garnered significant attention because of their probable adverse impacts on human health and the environment.This study examines UVs levels in sunscreens and isolation cosmetics and further assesses human exposure to UVs through the application of cosmetics.The total concentrations of nine UVs in 87 sunscreen and isolation cosmetic products ranged from 75.5 to 4.25×10^(4) ng/g.Among them,2-(2-hydroxy-5-methyl-phenyl)benzotriazole(UV-P)and 2-hydroxy-4-(octoxy)benzophenone(UV-531)had the highest concentrations.Use of the EpiSkin model indicated rapid absorption and strong dermal penetration by UV-328 following 36 h of exposure with a cumulative absorption rate of 41.8%±2.82%.Other congeners are expected to be distributed in the dermal tissue and donor fluid.Furthermore,this study explored potential mechanisms implicating skin biochemical barriers in the metabolism and transport of UVs.The potential of UVs to act as substrates and inhibitors of P450 enzymes was assessed,and their metabolites were predicted.Molecular docking simulations demonstrated that UVs can significantly interact and bind with three transport proteins in skin:MDR1,OATP2B1,and OATP3A1.Daily UVs exposure through the skin was assessed,revealing that dermal absorption levels of UV-P in sunscreen sprays(4.66×10^(3) ng/(kg bw day))and sunscreens(6.01×10^(3) ng/(kg bw day))were close to or exceeded the reference dose(RfD)and therefore require more attention.

关 键 词：ultraviolet absorbents SUNSCREEN dermal exposure dermal penetration risk assessment 

分 类 号：TQ658[化学工程—精细化工]