Current Phthalate Exposure Risks of Rural Population in the Northwest China: Evidence from an Internal Exposure Study  

作　　者：Yawen Zheng Liting Hua Zining Zhang Lin Zhu Hongkai Zhu Hongwen Sun Hongzhi Zhao 

机构地区：[1]Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria,College of Environmental Science and Engineering,Nankai University,Tianjin 300350,China [2]School of Urban and Environmental Sciences,Key Laboratory of the Ministry of Education for Earth Surface Processes,Peking University,Beijing 100871,China [3]State Key Laboratory of Environmental and Biological Analysis,Department of Chemistry,Hong Kong Baptist University,Hong Kong,China

出　　处：《Environment & Health》2024年第8期586-595,共10页环境与健康（英文）

基　　金：The authors gratefully acknowledge financial support from the National Natural Science Foundation of China(42177412);Ministry of Education of China(B17025).

摘　　要：Phthalates(PAEs)are synthetic chemicals widely used in industrial and personal consumer products as adhesives or plasticizers.PAEs have been demonstrated to have toxic effects on the human body.However,biological monitoring data for the internal PAE exposure levels of Chinese rural residents are still limited.The present study investigated the exposure levels of ten phthalate metabolites(mPAEs)of rural residents in Northwest China.The results showed that mPAEs were wildly prevalent in urine and the geometric mean concentration ofΣ10mPAEs was 957.02 ng mL^(–1)(adjusted by specific gravity).Mono-n-butyl phthalate(MBP)and metabolites of di(2-ethylhexyl)-phthalate(DEHP)were the most dominant mPAEs in urine,with specific gravity adjusted median concentrations of 174.67 and 156.30 ng mL^(–1),respectively.Urinary concentrations of mPAEs were significantly associated with age,body mass index and economic level(p<0.05).By calculating the percentage and relative conversion rate of DEHP metabolites,it was found that the degree of oxidative metabolism of DEHP in children was significantly higher than that in adults(p<0.05),indicating that the pathway and degree of DEHP oxidation were age-related.The risk assessment showed that 59.12%of rural residents may have a noncancer risk from PAE exposure.This study provides important basis for assessing the occurrence and exposure of urinary phthalate metabolites among rural residents in China.

关 键 词：Phthalate Metabolites Human Biomonitoring Health Risk Assessment Rural Residents 

分 类 号：R127[医药卫生—环境卫生学]