程序性细胞死亡在慢性难愈合创面炎症反应中的作用研究进展  

Research progresses on the role of programmed cell death in the inflammatory response of chronic refractory wounds

作　　者：陈雪莲[1] 刘琰[1] Chen Xuelian;Liu Yan(Department of Burn,Ruijin Hospital,Shanghai Burn Institute,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院灼伤整形科,上海市烧伤研究所,上海200025

出　　处：《中华烧伤与创面修复杂志》2024年第10期991-995,共5页Chinese Journal of Burns And Wounds

基　　金：国家自然科学基金面上项目(82072262,82072173);国家自然科学基金青年科学基金项目(82302796)。

摘　　要：持续炎症反应和反复组织损伤形成慢性炎性状态,是慢性难愈合创面的重要病理特征,在慢性难愈合创面的发生发展中发挥重要致病作用。多种类型的程序性细胞死亡可释放损伤相关分子模式,触发或诱导持续炎症反应,导致组织修复失调。该综述将从产生损伤相关分子模式角度,概述程序性细胞死亡在慢性难愈合创面炎症反应中的已知作用,探讨程序性细胞死亡在慢性难愈合创面中作用及其机制的可能研究方向。Continuous inflammatory response and repeated tissue damage lead to a chronic inflammatory state that is an important pathological feature of chronic refractory wounds,and plays an important pathogenic role in the occurrence and development of chronic refractory wounds.Multiple types of programmed cell death can release damage-associated molecular patterns,and trigger or induce sustained inflammatory responses,leading to dysregulated tissue repair.This review will outline the known role of programmed cell death in the inflammatory response of chronic refractory wounds from the perspective of generating damage-associated molecular patterns,and explore possible research directions on the role and mechanism of programmed cell death in chronic refractory wounds.

关 键 词：伤口愈合 炎症 慢性难愈合创面 程序性细胞死亡 损伤相关分子模式 

分 类 号：R641[医药卫生—外科学]