胰岛β细胞衰老与2型糖尿病的研究进展  

Advance in isletβ-cell senescence and type 2 diabetes mellitus

作　　者：郑瑶 陈刚[1] 林纬[1] Zheng Yao;Chen Gang;Lin Wei(Department of Endocrinology,Fujian Provincial Hospital,Shengli Clinical Medical College of Fujian Medical University,Fuzhou350001,China)

机构地区：[1]福建医科大学省立临床医学院,福建省立医院内分泌科,福州350001

出　　处：《中华内分泌代谢杂志》2024年第8期705-709,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：福建省卫生健康中青年领军人才研修培养项目资助(闽卫人函[2023]26号)。

摘　　要：2型糖尿病是一种发病机制复杂,以胰岛素抵抗、β细胞数量减少与功能障碍为特征的疾病。细胞衰老是细胞应对各种应激刺激而发生永久性增殖阻滞的过程。本文对胰岛β细胞衰老与2型糖尿病的研究进展进行综述,以期对胰岛β细胞衰老的机制,2型糖尿病中的β细胞功能障碍,以及靶向衰老机制的β细胞衰老与2型糖尿病的治疗策略有进一步了解。Type 2 diabetes mellitus is a complex disease characterized by insulin resistance,decreasedβcell mass and dysfunction.Cell senescence refers to the permanent proliferation arrest of cells in response to various stress stimuli.This review summarizes the research progress on pancreatic isletβcell senescence and type 2 diabetes,aiming to provide a deeper understanding of the mechanisms underlyingβcell senescence,βcell dysfunction in type 2 diabetes,and related therapeutic strategies.

关 键 词：Β细胞 衰老 糖尿病 2型 细胞再生 去分化 转分化 

分 类 号：R587.1[医药卫生—内分泌]