I_(2)-DMSO-Mediated Multicomponent [2+1+1+1] Annulation Reaction via Ethyl Nitroacetate C-NO_(2), Bond Cleavage as a C1 Synthon: A Route to Multisubstituted β-Pyrrolidinones Derivatives with a Quaternary Center  

作　　者：Zhi-Cheng Yu Xi Shen You Zhou Xiang-Long Chen Li-Sheng Wang Yan-Dong Wu An-Xin Wu 

机构地区：[1]National Key Laboratory of Green Pesticide,International Joint Research Centerfor Intelligent BiosensorTechnologyand Health,Collegeof Chemistry,Central ChinaNormal University,Wuhan,Hubei 430079,China

出　　处：《Chinese Journal of Chemistry》2024年第17期2029-2034,共6页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant 22171098);supported by Chengdu Guibao Science&Technology Co.,Ltd.and the 111ProjectB17019.

摘　　要：A[2+1+1+1]cyclization reaction has been developed for the synthesis of multisubstituted 6-pyrrolidinones from commercially available aryl methyl ketones,primary amines,and ethyl nitroacetate.In this I_(2)-DMSO-meditated process,the C-NO_(2) bond of ethyl nitroacetate is cleaved,affording a C1 synthon,and the formation of two C-C and two C-N bonds and a quaternary carbon center are constructed in one pot.This method has good substrate compatibility and permits the late-stage modification of pharmaceutical compounds.

关 键 词：CYCLIZATION Multisubstitutedβ-pyrrolidinones I_(2)-DMSO C1 building blocks Quaternary carbon center Late-stage modification Cracking 

分 类 号：O62[理学—有机化学]