Emerging Bio-relevant Applications of Polymer Mechanochemistry  

作　　者：Wenjie Liu Hai Qian 

机构地区：[1]State Key Laboratory of Molecular Engineering of Polymers,Department of Macromolecular Science,Fudan University,Shanghai 200438,China

出　　处：《Chinese Journal of Chemistry》2024年第17期2066-2070,共5页中国化学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(22271061);the startup funds from State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science at Fudan University。

摘　　要：Polymer mechanochemistry has rapidly evolved since the mid-20o0s.Recent advancements highlight the development of mechanophore platforms for the controlled release of bioactive payloads and the exploration of biocompatible activation strategies.These platforms,ranging from furan-maleimide Diels-Alder adducts to disulfide motifs withβ-carbonate linkages,demonstrate promising prospects in targeted drug delivery.Additionally,supramolecular assemblies and free radical-generating mechanophores present innovative avenues for potential therapeutic applications.Biocompatible activation methods,notably high-intensity and/or low-intensity focused ultrasound,hold potential for in vivo applications.However,challenges persist in comprehending the fundamental physics of ultrasound and its utilization for activation.

关 键 词：Polymer mechanochemistry Mechanophores Bio-relevant applications Ultrasound Drug delivery 

分 类 号：O62[理学—有机化学]