Deletion of V483 in the spike confers evolutionary advantage on SARS-CoV-2 for human adaptation and host-range expansion after a prolonged pandemic  

作　　者：Can Yue Shuo Liu Bo Meng Kaiyue Fan Sijie Yang Pan Liu Qianhui Zhu Xin Mao Yuanling Yu Fei Shao Peng Wang Youchun Wang Ravindra Kumar Gupta Yunlong Cao Xiangxi Wang 

机构地区：[1]CAS Key Laboratory of Infection and Immunity,National Laboratory of Macromolecules,Institute of Biophysics,Chinese Academy of Sciences,Bejing,China [2]Changping Laboratory,Beijing,China [3]Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing,China [4]Institute of Therapeutic Immunology&Infectious Disease(CITIID),University of Cambridge,Cambridge,UK [5]University of Chinese Academy of Sciences,Beijing,China [6]Biomedical Pioneering Innovation Center(BIOPIC),Peking University,Beijing,China [7]Joint Graduate Program of Peking-Tsinghua-NIBS,Academy for Advanced Interdisciplinary Studies,Peking University,Bejing,China

出　　处：《Cell Research》2024年第10期739-742,共4页细胞研究（英文版）

基　　金：supported by the National Key R&D Program(2023YFC2306000 and 2018YFA0900801);the Ministry of Science and Technology of China(CPL-1233 and SRPG22-003),CAS(YSBR-010);the National Science Foundation Grants(12034006,32325004 and T2394482);supported by the National Science Fund for Distinguished Young Scholar(32325004);the NSFS Innovative Research Group(81921005).

摘　　要：Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has undergone continuous evolution since its initial outbreak in 2019.The emergence of Omicron as the dominant variant occurred abruptiy after 2022.1 A highly mutated Omicron variant,BA.2.86,has recently been identified and reported in multiple countries.The global prevalence of this variant is gradually increasing,as confrmed by the World Health Organization(WHO),which has categorized it as a variant under monitored(VUM).2 The Spike(S)protein of BA.2.86 has achieved more than 30 amino acid changes since its divergence from the parental BA.2 strain.Among these changes,the deletion of residue 483(A483)in the receptor binding domain(RBD)region stands out(Fig.1a;Supplementary information,Fig.S1),as deletions in the S protein typically occur in the N-terminal domain(NTD)region of SARS-CoV-2 variants.Interestingly,the absence of residue 483 has been observed in SARs.3 Phylogenic and receptor usage analysis revealed that A483 is widespread among sarbecoviruses and is not linked to ACE2 binding4(Fig.1b).Moreover,the deletion is genetically stable and can be sustained.

关 键 词：sustained residue EXPANSION 

分 类 号：R563.1[医药卫生—呼吸系统]