New perspective on the treatment of rheumatic arthritis based on“strengthening body resistance(Fú Zhèng)”in the theory of co-inhibitory receptor-regulated T-cell immunity  

作　　者：Yifei Xu Linda Zhong Qianqian Liang Hao Xu 

机构地区：[1]Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai,China [2]Biomedical Sciences and Chinese Medicine,School of Biological Science,Nanyang Technological University,Singapore,Singapore [3]Spine Institute,Shanghai University of Traditional Chinese Medicine,Shanghai,China [4]Key Laboratory of Theory and Therapy of Muscles and Bones,Ministry of Education(Shanghai University of Traditional Chinese Medicine),Shanghai,China

出　　处：《Acupuncture and Herbal Medicine》2024年第3期290-294,共5页针灸和草药（英文）

基　　金：supported by the National Innovation and Entrepreneurship Training Program for College Students(202310268058);Exploration of the Mechanism on Therapeutic Efficacy of Gulong Capsules in Treatment of Osteoarthritis from the Perspective of Multi-omics(E4-H23066).

摘　　要：Co-inhibitory receptors serve as crucial regulators of T-cell function,playing a pivotal role in modulating the delicate balance between immune tolerance and autoimmunity.Initially identified in autoimmune disease models,co-inhibitory receptors,including CTLA-4,PD-1,TIM-3,and TIGIT,were found to be integral to immune regulation.Their blockade or absence in these models resulted in the induction or exacerbation of autoimmune diseases.Additionally,scholars have observed that co-inhibitory receptors on lymphocytes hold the potential to influence the prognosis in the context of chronic inflammation.Consequently,the blocking of co-suppressor receptors has emerged as a novel therapeutic approach for inhibiting refractory inflammatory diseases,particularly rheumatoid arthritis.From the standpoint of traditional Chinese medicine(TCM),the treatment of rheumatoid arthritis based on the“strengthening body resistance(FúZhèng)”theory can be construed as the regulation of co-suppressor receptors to modulate the body’s immune function in combating chronic inflammation.This article provides a succinct overview of the role of co-suppressor receptors in anti-inflammatory processes and explores the research prospects of co-suppressor receptor intervention in the treatment of rheumatoid arthritis.The exploration integrates the“strengthening body resistance(FúZhèng)”theory with relevant Chinese medicine formulations.

关 键 词：Combination of Chinese and Western Medicine Co-inhibitory receptors Rheumatic arthritis T-cell exhaustion 

分 类 号：R593.22[医药卫生—内科学]