Prevalence and outcomes of neonates with severe COVID-19:An observational study at Children’s Hospital 1 in Ho Chi Minh City,Vietnam  

作　　者：Phung Nguyen The Nguyen Tran Thanh Thuc Nguyen Thanh Hung Ngo Ngoc Quang Minh Dang Quoc Duy Tran Minh Nhut Nguyen Hoang Dung Tran Nguyen Ai Nuong Dinh Nguyen Cam Tu 

机构地区：[1]Department of Pediatrics,University of Medicine and Pharmacy at Ho Chi Minh city,Ho Chi Minh City,Vietnam [2]Children’s Hospital 1,Ho Chi Minh City,Vietnam [3]Pediatric Department,School of Medicine,Vietnam National University Ho Chi Minh City,Vietnam

出　　处：《Asian Pacific Journal of Tropical Medicine》2024年第9期392-399,I0001,共9页亚太热带医药杂志（英文版）

摘　　要：Objective:To evaluate the impact of the severe COVID-19 pandemic on neonates and develop strategies to improve their outcomes.Methods:We conducted an observational cross-sectional study at Children's Hospital 1(CH1)from July 25,2021,to May 31,2022.All neonates who had fever or respiratory symptoms or were born from mothers with COVID-19 and had a positive RT-PCR SARS-CoV-2 result would be included.We classified neonates with COVID-19 into 2 groups:mild/moderate and severe for analysis.Differences between groups were analyzed using Fisher's exact test/Chi-square test for categorical variables and Student's t-test/Wilcoxon Rank Sum test for continuous variables.Results:This study included 88 newborns who had positive RT-PCR SARS-CoV-2 results.The severity COVID-19 rate among neonatal cases was found to be 13.6%(12/88),with a corresponding mortality rate of 1.1%(1/88).All severe cases showed lung abnormalities as evident on chest X-ray images.In addition to respiratory symptoms,a higher incidence of gastrointestinal manifestations,such as vomiting and diarrhea,was observed in the severe group,indicating a compelling association.The administration of anticoagulant and anti-inflammatory drugs in the study group resulted in a satisfactory outcome with no significant complications.Conclusions:The COVID-19 pandemic has had a substantial impact on the well-being of neonates.The management of COVID-19 in this population presents significant challenges.

关 键 词：COVID-19 NEONATE ANTI-INFLAMMATORY ANTICOAGULANT 

分 类 号：R722.1[医药卫生—儿科] R563.1[医药卫生—临床医学]