冠状动脉周围脂肪组织与冠心病预后关系的研究进展  

Research progress of pericoronary adipose tissue and prognosis of coronary heart disease

作　　者：徐媛 郭歌[2] 蔡嘉庚 蔡珠兰 吴岑岑 赵鹏辉 祖凌云[1] Xu Yuan;Guo Ge;Cai Jiageng;Cai Zhulan;Wu Cencen;Zhao Penghui;Zu Lingyun(Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University,NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Peking University,Beijing Key Laboratory of Cardiovascular Receptors Research,Beijing 100191,China;Department of Cardiology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院心内科、血管医学研究所,血管稳态与重构全国重点实验室,国家卫生健康委心血管分子生物学与调节肽重点实验室,心血管受体研究北京市重点实验室,100191 [2]北京大学第三医院放射科,100191

出　　处：《中国心血管杂志》2024年第5期453-456,共4页Chinese Journal of Cardiovascular Medicine

基　　金：第二次青藏高原综合科学考察研究专项(2019QZKK0606);国家重点研发计划项目(2022YFB3807300);北京大学第三医院临床队列建设项目(BYSYDL2022005);北京大学第三医院临床重点项目(BYSYZD2023006)。

摘　　要：冠状动脉周围脂肪组织(PCAT)是指距离冠状动脉壁血管直径范围内的脂肪组织,其可以与邻近的冠状动脉进行双向通讯,调节局部冠状动脉炎症。PCAT对冠心病预后的预测价值在多项研究中已得到验证。因此,本文就PCAT与冠状动脉相互作用的病理生理机制及其与冠心病预后关联的研究进展作一综述。Pericoronary adipose tissue(PCAT)refers to the adipose tissue surrounding coronary arteries,which can communicate with neighboring coronary arteries in a bidirectional manner and regulate local coronary artery inflammation.The predictive value of PCAT for the prognosis of coronary heart disease has been validated in several studies.Therefore,this article reviews the pathophysiologic mechanisms of PCAT interaction with coronary arteries and the research progress related to the prognosis of coronary heart disease.

关 键 词：冠状动脉周围脂肪组织 脂肪衰减指数 冠状动脉炎症 冠状动脉性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]