微小RNA靶基因调控的信号通路在急性心肌梗死演进过程中作用的研究进展  

Research progress of microRNA-mediated signaling pathways in the progression of acute myocardial infarction

作　　者：侯谦 马雅楠 刘德敏[1] Hou Qian;Ma Yanan;Liu Demin(Department of Cardiology,the Second Hospital of Hebei Medical University and Institute of Cardiocerebrovascular Disease of Hebei Province,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院心内一科河北省心脑血管病研究所,石家庄050000

出　　处：《中国心血管杂志》2024年第5期486-491,共6页Chinese Journal of Cardiovascular Medicine

基　　金：国家自然科学基金(82100301);河北省自然科学基金(H2024206277)。

摘　　要：急性心肌梗死(AMI)作为心血管疾病的危重症,是导致全球心血管疾病死亡的主要原因之一。近年来,越来越多的研究揭示了信号通路在AMI过程中发挥的作用,微小RNA(miRNAs)对AMI中信号通路的调控也逐渐得到重视。本文总结了miRNAs介导的信号通路在AMI中的作用,以期为miRNAs治疗应用于临床提供理论依据。As a critical condition among cardiovascular diseases,acute myocardial infarction(AMI)is one of the leading causes of mortality worldwide.In recent years,accumulating studies have revealed the role of signaling pathways in the progression of AMI.In addition,the mechanism of microRNA-mediated signaling pathways in AMI has gained significant attention.This review summarizes the important roles of microRNA-mediated signaling pathways in the progression of AMI,aiming to provide a theoretical basis for clinical application of microRNA therapy.

关 键 词：微小RNA 靶基因 急性心肌梗死 信号通路 

分 类 号：R542.22[医药卫生—心血管疾病]