2,3,4,5-四氟苯甲酸的合成方法研究进展  

Advances in the Synthesis of 2,3,4,5-tetrafluorobenzoic Acid

作　　者：张德胜 徐鹏飞 田强 祝丽君 李自龙 Zhang Desheng;Xu Pengfei;Tian Qiang;Zhu Lijun;Li Zilong(Yunnan Yuntianhua Co.,Ltd.,R&D Center,Kunming 650228,China)

机构地区：[1]云南云天化股份有限公司研发中心,云南昆明650228

出　　处：《云南化工》2024年第10期47-53,共7页Yunnan Chemical Technology

摘　　要：2,3,4,5-四氟苯甲酸(TFBA)是一种重要的药物中间体,广泛应用于医药、农药的合成,研究TFBA的合成方法具有重要的现实意义。综述了TFBA合成方法(邻苯二甲腈法、四氟苯法、四氟邻苯二甲酸法、五氟苯甲酸法和邻苯二甲酸酐法等)的研究进展,分析和对比了各方法的优缺点,同时对TFBA的合成方法进行总结和展望,为TFBA的工业化生产及应用提供一定的理论基础。2,3,4,5-Tetrafluorobenzoic acid(TFBA)is an important pharmaceutical intermediate,widely used as a raw material for the synthesis of pharmaceuticals and pesticides,and the study of the synthetic method of TFBA is of great practical significance.This paper reviews the research progress of TFBA synthesis methods(phthalonitrile method,tetrafluorobenzene method,tetrafluorophthalic acid method,pentafluorobenzoic acid method and phthalic anhydride method,etc.),and analyses and compares the advantages and disadvantages of each method.Meanwhile,it also sums up and looks forward to the synthetic method of TFBA,which can provide certain theoretical basis for the industrial production and application of TFBA.

关 键 词：2 3 4 5-四氟苯甲酸 合成 应用 

分 类 号：TQ245.1[化学工程—有机化工]