茶树油微乳的制备及体外评价研究  

Preparation and in Vitro Evaluation of Tea Tree Oil Microemulsion

作　　者：张嘉嘉 蓝琳舒 李佳 李康银 徐冬梅 Zhang Jiajia;Lan Linshu;Li Jia;Li Kangyin;Xu Dongmei(Yuxi Agriculture Vocational Technical College,Yuxi 653106,China)

机构地区：[1]玉溪农业职业技术学院,云南玉溪653106

出　　处：《云南化工》2024年第10期68-73,共6页Yunnan Chemical Technology

基　　金：云南省教育厅科学研究基金项目,编号:2023J1840。

摘　　要：目的:采用星点设计-效应面法优化茶树油微乳的配方与制备,并对最优配方进行体外评价研究。方法:通过伪三元相图筛选茶树油微乳的配方组成;固定油相质量分数,采用星点设计-效应面法以混合乳化剂的质量分数和乳化剂与助乳化剂的比例为考察因素,微乳粒径、Zeta电位及多分散系数PI为效应值,采用Design-Expert8.05b软件筛选并验证最优配方,将优化配方进行体外评价试验。结果:茶树油微乳最佳配方为:油相(茶树油)质量分数为5%,乳化剂(Kolliphor RH40)质量分数为11.12%,助乳化剂(Trabscutol P)质量分数为15.44%,水质量分数为68.44%;其平均粒径为17.53 nm, Zeta电位为-16.36 mv, PI为0.035;茶树油微乳体外12 h累积透皮量是茶树油稀释液的3倍,稳定性良好。结论:星点设计-效应面法所建立的模型预测性良好,能方便准确地得到茶树油微乳的较优配方,可为茶树油临床制剂的研发提供参考。(Objective)To study the formulation and preparation of tea tree oil microemulsion by the central composite designresponse surface method and to evaluate its quality.(Methods)The selection of tea tree oil microemulsion prescription were screened by the pseudo-trigram.Fixed mass fraction oil phase,with the mass fraction of mixed emulsifier and the proportion of emulsifier and auxiliary emulsifier to examine factors,particle size,zeta potential of microemulsion and multiple effects of dispersion coefficient PI for value,using the Design-Expert 8.05b software filter and verify the optimal prescription.(Results)The best prescription for tea tree oil micromilk was:oil phase(tea tree oil)5%,emulsifier(Kolliphor RH40)11.12%,and coemulsifier(Trabscutol P)15.44%,water 68.44%;The average particle size is 17.53 nm,and Zeta potential is-16.36,PI is 0.035.The total volume of 12h of tea tree oil was 3 times that of tea tree oil diluents.(Conclusions)The design of the central design-response surface method can easily obtain the better prescription of the tea tree oil microemulsion,and the model prediction is good,which provides reference for the research and development of clinical preparations of tea tree oil.

关 键 词：茶树油 微乳 星点设计-效应面法 

分 类 号：R943[医药卫生—药剂学]